Nano-BioTransporter

Polymer-particle light-cleavable carrier systems for photodynamic therapy (PDT) Cancer is one of the main causes of death worldwide. One of the newer therapeutic approaches is photodynamic therapy (PDT), a treatment that uses a photosensitizing chemical substance, a particular type of light and oxygen.

A Novel Marker for Brown Fat Activity

Exosomal microRNA-92 in serum reflects brown fat activity Brown adipose tissue (BAT) is a special type of fat, which regulates the body temperature by fatty acid oxidation.

Diagnosis of osteoarthritis

Thrombospondin-4 autoantibodies for the diagnosis of osteoarthritis Osteoarthritis (OA) is the most common degenerative disease of joints world-wide. About two-third of people over 65 years are affected, whereas the etiology is largely unclear.

Novel Anti-Tuberculosis Compounds

The resurgence of tuberculosis, caused primarily by Mycobacterium tuberculosis (Mtb), and the appearance of multi‐drug and extensively drug resistant Mtb strains strengthen the need for new drugs with alternative modes of action.

Cartilage-specific antimicrobial CLEC3A

Bacterial infection is one of the most frequent complications in joint replacement and dental implant surgery. The incidence of septic arthritis following total joint arthroplasty is approximately 2%, leading to massive health problems and considerable cost to the national economy.

Monitoring of hemophilia

Utilizing PD1 as a biomarker for monitoring immune tolerance of coagulation factor VIII treatment of hemophilia A patients The invention relates to PD1 as a biomarker for monitoring immune tolerance of coagulation factor VIII treatment of hemophilia A patients.

OptoRyR

Light-induced opening of Ryanodine receptors Light-induced opening of the Ryanodine receptor for use as a scalable system in drug screening.

SafeGuard-BR system

A lockable intubation adapter system for safe respiratory tract access against infection and contamination The lockable intubation adapter system allows hygienic, protected performance of intensive-care examinations without releasing infectious aerosol particles or droplets into the ambient atmosphere.

ITIH3 - a biomarker for Myasthenia gravis activity

A novel ELISA-based approach The invention aims at monitoring inter-alpha-trypsin inhibitor heavy chain H3 (ITIH3) in the serum of Myasthenia gravis patients as the first biomarker for the assessment of MG disease activity in clinical routine, e.g. for therapy adjustments. Monitoring can easily be made by quantitative ELISA in routine blood collection.

Parthenolide supports PNS repair

Parthenolide and its derivatives for use in the treatment of axonal damage Peripheral nerve damage is a common cause of considerable functional morbidity, and healthcare expenditure.

Synthetic Cytokine Receptors

Synthetic cytokine receptors to control cellular activity Synthetic cytokine receptors (SyCyRs) enable defined background-free cellular responses through addition of synthetic ligands. The system allows the engineering of highly specific amplification or eradication switches for recombinant cells.

Improving aspirin solubility

A method for the production of acetylsalicylicacid-nicotinic acid amide co-crystals with improved solubility. Acetylsalicylic acid (ASA) is one of the most prescribed non-steroidal anti-inflammatory drugs. However, the substance suffers from poor water solubility.

Vim3 and Mxi-2 antibodies

Non-invasive markers for diagnosis and differentiation of benign and malignant renal carcinoma The invention relates to Vimentin3 and Mxi-2 antibodies found for the non-invasive diagnosis of kidney tumors. These antibodies can make a clear differentiation of oncocytoma and RCC types and allow targeted therapeutic measurements.

Novel therapy for Metachromatic Leukodystrophy

A SuPerTurbo-ASA – An engineered enzyme for use in gene therapy and enzyme replacement therapy The technology relates to a variant of the enzyme arylsulphatase A characterised by increased blood-brain barrier permeability, catalytic activity and half-life, and which is suitable for the treatment of metachromatic leukodystrophy by an enzyme replacement therapy.

EasyDMEK Shooter and PrepLoad Tool

Novel tool for controlled unfolding and atraumatic positioning of the Descemet membrane (DC) & device for contactless preparation and transfer of DCs The invention comprises a DMEK injection device with a special design, which simplifies the release and unfolding of the membrane into the recipient´s eye during surgery. 

Extracorporeal apheresis to treat preeclampsia

A novel VEGF-multimer based approach Pre-eclampsia is caused by an imbalance between the pro-angiogenic factors VEGF and PIGF and the anti-angiogenic factor sFlt-1, because sFlt-1 binds both factors. This binding leads to the inactivation of VEGF and PIGF. The present invention relates to a method by which sFlt-1 is eliminated from blood in an apheresis procedure.

New Cryptophycins for ADC and SMDC

New conjugation of cryptophycins for use in ADC (antibody-drug conjugates) and SMDC (small molecule drug conjugates) The present invention combines new synthetic ways to new Cryptophycin derivatives with alternative conjugation possibilites and pico-molar cytotoxicies, for ADC and SMDC synthesis.

Treatment of ocular hypertension

Dual Targeting in a New Class of Anti-Glaucoma Agents Increased intraocular pressure (IOP), also known as ocular hypertension, is widely associated with open-angle and narrow-angle glaucoma. These servere eye diseases may lead to blindness. Current therapeutic approaches use carbonic anhydrase inhibitors (CA Inhibitors), beta blockers, alpha2-receptor agonists, prostaglandins and...

Supplements for T Cell-Based Immunotherapy

T Cell Activation and Prevention of Exhaustion in the treatment of cancer Optimized conceot for the activation of CAR T cells and prevention of exhaustion in the treatment of cancer.

SelectCells

Extremely mild, selective and efficient technique for separating cells Extremely mild, selective and efficient technique for separating cells based on temperature-sensitive polymer coating, particularly stem and iPS cells.

Monitoring of hemophilia

Utilizing PD1 as a biomarker for monitoring immune tolerance of coagulation factor VIII treatment of hemophilia A patients The invention relates to PD1 as a biomarker for monitoring immune tolerance of coagulation factor VIII treatment of hemophilia A patients.

Artificial Interferons

Interferon alpha 2 mutants with improved anti Hepatitis B virus activity The invention comprises IFNα2 mutants achieved by designing an IFNα2 with amino acids from IFNα14, which significantly improved their antiviral activity against chronic HBV. As IFNα14 is not suitable for use as a drug, unlike IFNα2, and considering that the IFNα2 mutant is almost as effective as IFNα14, it appears the...