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Biological coatings have a high potential for manifold applications, especially for medical applications or biodegradable coatings. Up to now, the formation of biological coatings is accompanied either by a low control over film formation or connected to high costs. Current challenges that need to be overcome are a high control over the film thickness, an even and continuous coating of objects with a complex geometry, or the site-specific coating of single areas on one object.
The new concept Enzymatic Bio-Coating is able to solve these problems and at the same time exhibits low costs. In this new process, film-forming particles are deposited from a dispersion in direct proximity to a support surface by destabilization of the dispersion. To this, the presented concept uses immobilized enzymes to „trigger“ the deposition reaction. Enzyme is immobilized onto the support surface and destabilizes film-forming particles closely to the support. The destabilized particles subsequently deposit only there, where immobilized enzyme is present (Fig.1). This is practically realized by a simple dipping process.
Depending on the applied immobilization method, various structures are obtained, which range from the deposition of single micelles to the formation of monolayers to the deposition of hybrid structures (Fig. 2).
High biocompatibility and biodegradability of proteins allows for versatile medical applications (Stents, implants, catheters). Specific deposition of single particles has a high potential for micro- and nano-technology. Immersion of two enzyme-functionalized supports in a casein dispersion enables a pressureless gluing of both supports, exactly only there, where immobilized enzyme is present.
Suitable supports are: Glass, wood, and miscellaneous plastics and metals.
Casein layers are antibacterial, edible, and renewable.
An international patent application for Enzymatic Bio-Coating is already pending.
The process was investigated with casein which forms micelles in aqueous environments, and with the protease chymosin, but is not restricted to this system.
PROvendis offers licenses for Enzymatic Bio-Coating on behalf of the University of Paderborn to companies and seeks partners for exploration of specific applications.