Acetylsalicylic acid (ASA) is one of the most prescribed non-steroidal anti-inflammatory drugs. ASA has an analgesic, anti-inflammatory and antipyretic effect and prevents platelet aggregation. Due to its effects on blood clotting, ASA is also used for cardiovascular prophylaxis and to prevent strokes in high-risk patients. 

A significant technical disadvantage of ASA is its very low water solubility. In order to solve this problem, many research groups and companies have been working for a long time on the question of how to improve the water solubility of ASA and thus also its absorption and bioavailability.

The invention provides a reproducible method of producing ASA-nicotinic acid amide co-crystals with improved solubilty and bioavailability.