Our technology offers from the fields of Applied Sciences and Life Sciences:
Here you will find innovations protected by property rights from the universities of North Rhine-Westphalia and other research institutes, selectable by technological field. All technologies were evaluated for commercial feasibility and patentability.
Regardless of your own R&D activities you can acquire interesting innovations and thereby minimize the economic risk to your business. In case of interest we can connect you with research partners for successful collaboration.
SelectCells
Extremely mild, selective and efficient technique for separating cells based on temperature-sensitive polymer coating, particularly stem and iPS cells.
Precise photoacoustic gas sensor
The quantitative verification of specific gases in a mixture is technically challenging, so microsystemic sensors often return large measurement errors. A new miniaturized photoacoustic gas sensor from the Technical University of Dortmund can help by detecting target gases very precisely and selectively. A gas sample is radiated from a pulsed light source of suitable wavelength, heating the gas molecules to the proper absorption band.
Multiple Tones Extension (MTE)
Wireless systems are used not only for communication, but also for such secondary applications as localization. In recent years, the cost advantages of Bluetooth indoor localization systems in particular in such areas as asset tracking have led to great popularity.
Treatment of ocular hypertension
Increased intraocular pressure (IOP), also known as ocular hypertension, is widely associated with open-angle and narrow-angle glaucoma. These servere eye diseases may lead to blindness. Current therapeutic approaches use carbonic anhydrase inhibitors (CA Inhibitors), beta blockers, alpha2-receptor agonists, prostaglandins and cholinergics.
Recycling of coated light metals
Much of Europe has a circular economy in which most metallic materials, such as various construction materials and beverage cans made of aluminum, are recycled. Fundamentally, two different forms of aluminum is used in industry.
Non-invasive glucose measurement
Regular blood sugar measurement is important for diagnosing and treating diabetes mellitus, a metabolic disorder characterized by high blood sugar. Blood sugar can be measured in a variety of ways, but the current method of choice is invasive: a small blood sample to determine sugar concentration.
Optical magnetometer current measuring system
Optical current measuring systems are one way of measuring electric current touchlessly and contactlessly. They use light to determine current precisely. The advantage is that optical transformers are compact, saturation-free, linear, and high-precision. They can detect very large and very small currents in a broad frequency range.
Diagnostic tool for plasma processes
Low-temperature plasmas are used in semiconductor and medical technology and surface engineering. Production process precision and production reproducibility are a growing challenge, especially in semiconductor technology, where components are becoming increasingly smaller.
Active interference-suppressed power electronics
High-frequency circuits can cause electromagnetic emissions that impair other electronic systems. In power electronics, it is therefore often necessary to suppress EMC interference by such means as active narrowband filters.
Photocage Cap for mRNAs
Almost all eukaryotic messenger RNAs (mRNAs) are modified at their 5'-ends by a cap that is synthesised by addition of a 7-methylguanosine attached via a 5'-5' triphosphate bridge to the first transcribed nucleotide of the mRNA chain.
KatTex
Industrial filter bags with catalytic properties are state of the art. They consist of a multi-layer fabric, containing catalytic particle in the intermediate space. Due to this construction, there is a huge pressure lost and cost for an additional fabric layer.
3D ambisonic microphone
Home theater, gaming and VR applications increasingly rely on three-dimensional surround sound, however, low and very low tones in particular are inadequately reproduced.
Artificial Interferons
The invention comprises IFNα2 mutants achieved by designing an IFNα2 with amino acids from IFNα14, which significantly improved their antiviral activity against chronic HBV. As IFNα14 is not suitable for use as a drug, unlike IFNα2, and considering that the IFNα2 mutant is almost as effective as IFNα14, it appears the IFNα2 mutant could be a viable option for clinical application.
PICOihc
The invention pertains to an integrate-and-hold circuit which is used as a sampler. The typical structure of an integrate-and-hold circuit (IHC) is a multiplier serving as a switch followed by a resettable integrator with a hold capacitor.
Retrofit polarization-maintaining in optical fibers (PM)
The invention of the University of Bonn relates to the development of a method to retrofit polarization- maintaining (PM) optical fibers in a way, that a routinated achievement of polarization to a degree better than 10-5 in extinction ratio takes place.
Aptamer D3P-21
Prostate cancer is the most common cancer among men. In particular, hormone refractory prostate cancer is not curable and targeted therapies are yet not available.
Adaptive Controller
The invention makes optimum use of continuous-value manipulated variables in a closed-loop control system. In this way, the control behavior is improved because the controlled system operates less erratically. As a result, energy consumption and wear are significantly reduced and user comfort is increased.
Antireflective integrated optical waveguide
In transitions between dielectric optical waveguides of different thickness, it comes through modal mismatch usually to radiation losses and optical backscatter.
Air-Retaining-Grids
The present invention "Air-Retaining Grids Technology" describes a new possibility for the architecture and construction of surfaces which are able to keep a layer of gas stable even under changing pressure conditions when immersed in liquid. Structured, non-wettable surfaces are used for various applications, for example as self-cleaning surfaces.
OsteoProtect
There are currently 200 million people suffering from osteoporosis worldwide. Low bone mass and deteriorating bone quality lead to an increased risk of fractures, high morbidity and increased mortality.
Rotary piston pump
So far, the problem of sealing has been a major challenge when using rotary piston pumps.
MPTSC
For a fast and precise control of mechatronic systems usually non-linear PID controllers are used. The more nonlinearities a system contains, the more complex the control task becomes.
TDTO (Three-Dimensional Titanium Oxide)
The present invention belongs to the technical field of rechargeable batteries and supercapacitors. Particularly, it relates to an electrode material for rechargeable batteries and electrochemical capacitors, a method for preparing the same, and rechargeable batteries as well as electrochemical capacitors.
Anode Material for Lithium-Ion Batteries
The presented technology offers methods for the synthesis and preparation of carbon coated metal oxide nanoparticles for application as anodic materials in lithium-ion batteries.
EasyDMEK Shooter and PrepLoad Tool
The invention comprises a DMEK injection device with a special design, which simplifies the release and unfolding of the membrane into the recipient´s eye during surgery. Therefore, the number of subsequent surgical steps and the likelihood of complications is reduced and consequently the success rate of this surgical method is increased. Corneal transplantation is the most successful organ transplantion in medicine and performed on patients with endothelial dysfunction. In a surgery procedure called DMEK (Descemet Membrane Endothelial Keratoplasty), the inner layer of the cornea, the Descemet's membrane, is replaced with a donor membrane. There is also a device for preparing a Descemet membrane endothelial graft and loading an injection or cultivation cartridge.
Combinatory Asthma Endoytping Assay
Asthma is a disease of several subtypes characterized by different severity and a distinct immunological background. Most importantly, several subtypes of allergic asthma need to be correctly identified and distinguished from forms of non-allergic asthma.
Click-Mass Spectrometry of lipids
Aberrations in fatty acid metabolism are associated with pathological states and have become a focus of current research, particularly due to the interest in metabolic overload diseases.
HTRA inhibitors
High Temperature Requirement A (HTRA) proteins are serine proteases of the S1 family (trypsin/chymotrypsin-like). HTRA1 is supposed to play a role in macular degeneration, and HTRA2 has been associated with cell death in reperfusion-ischemia.
Cartilage-specific antimicrobial CLEC3A
Bacterial infection is one of the most frequent complications in joint replacement and dental implant surgery. The incidence of septic arthritis following total joint arthroplasty is approximately 2%, leading to massive health problems and considerable cost to the national economy.
Diagnosis of osteoarthritis
Osteoarthritis (OA) is the most common degenerative disease of joints world-wide. About two-third of people over 65 years are affected, whereas the etiology is largely unclear.
O3Desi
Careful control of the patient's blood temperature is imperative in cardiac surgery. The heat exchangers used for this purpose are usually integrated in the oxygenator of the heart-lung machine.
CurrentShare
To reduce the input resistance of power modules, single semiconductor switches are usually connected in parallel.
Wireless Data Bus Bridge
At the Aachen University of Applied Science, a method for the transmission of data in a bus system was presented, which enables wireless communication between the bus users with the aid of a transceiver.
Brake resistor
To decelerate an electric motor, the remaining kinetic and magnetic energy must be removed from the system. This is usually done with brake resistors that convert the energy to heat.
Cyclic AMP Biosensor
Cyclic AMP is a key molecule in 2nd messenger cell signalling. Great effort has been taken to develop sensors that allow for noninvasive assessment of cAMP concentrations in living cells.
Anti-tuberculosis drug
Tuberculosis resulting from infection with Mycobacterium tuberculosis (Mtb) is a serious global health problem accounting for 1.7 million deaths in 2016. A major reason for the high morbidity and mortality caused by Mtb is the long duration of therapy and increasing multidrug-resistance of Mtb strains.
EF-Tu-binding Re-complexed antibiotics
A series of novel Re(I)-(CO)3-N-heterocyclic carbene (NHC) complexes bearing unsubstituted benzimidazol-2-ylidene ligands as well as a variety of bisimine ligands has been prepared and comprehensively characterised.
Opto-THC
Sample-and-hold circuits or track-and-hold (TH) circuits, along with analog-to-digital converters (ADCs), are the link from the analog to the digital world.
SMECS
The generation of cardiomyocytes (CMs) from pluripotent stem cells (PSCs) holds great promise for cardiac regenerative medicine.
Novel Anti-Tuberculosis Compounds
The resurgence of tuberculosis, caused primarily by Mycobacterium tuberculosis (Mtb), and the appearance of multi‐drug and extensively drug resistant Mtb strains strengthen the need for new drugs with alternative modes of action.
Novel Markers for Male Fertility Diagnosis
Infertility affects an estimated 15 percent of couples globally, amounting to 48.5 million couples. Forty percent of cases are linked to men. An important factor of male infertility is an insufficient quality of sperms due to abnormal shape and/or motility.
A Multifunctional Linker for CAR T-cells
Chimeric antigen receptors (CARs) have been developed for the molecular engineering of effector T-cells to be used in targeted cancer therapy. CARs consist of the antigen-binding single-chain fragment (scFv) of an antibody fused via a hinge region to a transmembrane domain (TM) and to one or more intracellular signalling co-stimulatory regions.
CEACAM1 antibodies for anti-viral therapy
Cytotoxic CD8-positive T cells constitute the crucial leukocyte subpopulation for a cellular response against viral infection.
WOOD-INSERT
Scientists from the Ostwestfalen-Lippe University of Applied Sciences have developed a wood or wood-based material insert for the partial reinforcement of panel-shaped lightweight construction elements in sandwich construction that can be inserted using conventional tools, hand tools, machines or machining centers.
WOOD-SPRING
Scientists at the Ostwestfalen-Lippe University of Applied Sciences have developed an inseparable connecting element for panel-shaped lightweight construction elements in sandwich construction, which can be used similarly to flat dowels for classic solid wood materials, including for sandwich elements.
HypoxieFit
Athletes, such as marathon runners and cyclists, often resort to training at higher altitude areas, in order to optimize their endurance. The atmosphere in such locations has lower oxygen content, which forces the human body to compensate for the reduced oxygen uptake by increasing hemoglobin concentration in blood.
Open FET Sensor
The Open FET sensor is a field-effect-based sensor in which the gate electrode is connected only to the signal to be measured and not as usual to other electronic components.
WiMDaD Wire Mesh Damage Detection
Composite materials are nowadays used in many technical fields. Blades of wind power plants or aircraft parts, for example, are made out of these materials.
Enantiomerically pure chiral N-acyl-a-aminonitriles
Enantiomerically pure N-acyl-a-aminonitriles gained these days interest in the pharmaceutical industry since a range of recently developed pharmaceuticals are based on this product class.
Full Inorganic Load Bearing Insulator
Scientists of the University of Duisburg-Essen developed in cooperation with the German Aerospace Center (DLR) a full inorganic insulation material with high performance qualities.
A Novel Marker for Brown Fat Activity
Brown adipose tissue (BAT) is a special type of fat, which regulates the body temperature by fatty acid oxidation.
P2Y 12-receptor antagonist
Purinergic receptors have been in the focus of drug discovery for many years. Modulation of P2 receptors in platelets is of paramount importance in regulating platelet function, and as a consequence, in controlling thrombotic diseases, which are the most common cause of morbidity and mortality in the Western world.
Parthenolide and its derivatives for use in the treatment of axonal damage
Peripheral nerve damage is a common cause of considerable functional morbidity, and healthcare expenditure.
Corallopyronin A as antifilarial drug
The novel anthelmintic natural compound Corallopyronin A (CorA) adresses the heartworm disease in dogs caused by the infection of Dirofilaria parasites (D. immitis and D. repens). The invention is in a late pre-clinical stage: Data are available concerning toxicology and pharmacology. A formulation of CorA is also under development. A production process of CorA has been set up.
Druggable oncogenic fusions
Cancer patients frequently bear therapeutically relevant genome alteration. For instance, lung adenocarcinomas of patients that have never smoked carry genome alterations affecting kinases, such as EGFR mutations and translocations affecting ALK, ROS1 and RET genes.
SWEETNANO
The presented technology is a newly developed sucrose supported synthesis of transition metal doped zinc oxide nanoparticles, which can be used as active material for the fabrication of high capacity anodes for lithium-ion batteries.
Epigenetics in AML
DNA-methylation (DNAm) of CpG dinucleotides is a key epigenetic process. Upon cell division, the DNAm pattern is maintained on the newly synthesized DNA strand by DNA methyltransferase 1 (DNMT1), whereas DNAm pattern changes are triggered by DNMT3A and DNMT3B that act as de novo methyltransferases.
Determination of the Biological Age
Biological age is influenced by parameters, such as genetic background, disease and lifestyle. Currently, the biological age can be assessed by measuring telomere length, DNA rearrangements or protein alterations.
ALXAN
Adenosine is a modulator of many physiological and pathophysiological processes in the central nervous system (CNS).
Exosomes
Exosomes are nano-sized, secreted cell organelles that are released by a huge variety of different cell species, including mesenchymal stem cells (MSCs). Containing a combination of lipids and proteins as well as RNAs, exosomes participate in intercellular communication processes.
Corallopyronin A as antifilarial drug
The novel anthelmintic natural compound Corallopyronin A (CorA) adresses Elephantiasis and River blindness caused by the infection with filarial nematodes (mainly by Wuchereria bancrofti, Brugia malayi, Brugia timori and Onchocerca volvulus). The invention is in a late pre-clinical stage: Data are available concerning toxicology and pharmacology. A formulation of CorA is also under development. A production process of CorA has been set up.
Senescence-Methylation-Signature
Long-term culture associated changes need to be considered for quality control of cell preparations. The invention discloses a simple method to track cellular aging based on continuous DNA-methylation changes at six specific CpG sites.
Diabrux
Diabrux is a user-friendly and the first bite film validated in clinical studies for the standardised, quantitative diagnosis of sleep bruxism. Diabrux is worn by the patient like a night splint. The device is based on a hard plate, which is covered by five specifically linked layers with different colours and defined abrasion properties. A fully automated evaluation software is provided for standardized, objective, quantitative analysis. Diabrux facilitates monitoring of bruxism activity. Thus, personalized therapy planning is possible and cost-intensive treatments can be scheduled more accurately.
Mitigate radio jamming cyberattacks
Driver assistance systems and automated vehicles offer numerous advantages - but the technology also harbors the risk of cyber-attacks that can hinder communication and jeopardize safety. A process has been developed at Hamm-Lippstadt University of Applied Sciences to detect and mitigate radio jamming in good time.
Rotor blades for low wind speeds
A rotor geometry modeled on maple seeds has been developed that enables more efficient operation of wind turbines and fans. It is a geometry that is easy to manufacture and cheaper to produce than conventional rotor blades.
GaN GIT driver circuit
A new gallium nitride driver circuit allows inverters and frequency converters to switch faster, enabling more efficient power electronics that can switch in the MHz range. The advantage of the new GaN driver circuit from Bonn-Rhein-Sieg University of Applied Sciences is that lower losses occur and higher power densities are achieved.
Fin plate
The device is particularly advantageous for the transportation and assembly of wind turbines. Vortex-induced vibrations are significantly reduced or avoided. In principle, the device can be used for all cylindrical structures (e.g. pillars) that need to be protected from vortex-induced vibrations.
Improving aspirin solubility
Acetylsalicylic acid (ASA) is one of the most prescribed non-steroidal anti-inflammatory drugs. However, the substance suffers from poor water solubility. The invention provides a reproducible method to produce ASA-nicotinic acid amide co-crystals with improved solubilty and bioavailability.
Rain gutter water level monitoring
Gutter blockages caused by leaves, dirt and other debris can prevent the flow of water in the gutter, which can lead to considerable damage and problems. Water can spill over the sides of the gutter, causing water damage to the foundations or other parts of the building. In addition, standing water in the gutter can attract insects such as mosquitoes and serve as a breeding ground. In colder climates, the accumulated water can freeze and form ice dams that damage the roof or the gutter itself. Researchers at the University of Siegen have found an innovative solution to this problem by equipping the gutters with a water level sensor.
Coupling Element
The developed coupling element is used to clamp the material sample to be tested in the test system, whereby the elongated sample is usually mounted parallel (and not orthogonally as is usually the case) to the ultrasonic wave to be introduced.
Procedure for orienting X-ray units
A new technology from Heinrich Heine University based on machine learning (MI) allows X-ray equipment to be automatically adjusted to the respective patient, regardless of the patient's position angle.
Seal effectiveness doubled
The sealing concept consists of two independent seals. This provides additional safety. The gaskets are particularly suitable for plastic flanges. Only low forces are required and leakages are avoided. Extensive measurements have already been carried out.
Supplements for T Cell-Based Immunotherapy
Optimized conceot for the activation of CAR T cells and prevention of exhaustion in the treatment of cancer.
Ü- Fix
In Germany alone, the annual healthcare expenditure for diabetic foot syndrome (DFS) is around 2.5 billion euros. Thanks to a new invention, it is now possible to replace the commercially available solutions for foot pieces, which are not optimally adapted to the needs and mobility requirements of patients, with a foot piece for the external fixator, which mechanically bridges the damaged area or fracture in such a way that the loads are applied proximally at this point during movement. The patient can now be mobilized directly regardless of the healing status.
Magnetic field focusing
Thanks to an invention by Bielefeld University of Applied Sciences and the use of a specially shaped ferrite sheath, the temperature distribution of induction hobs can be made more homogeneous and energy efficiency increased.
Feedback mechanism for powder inhalers
Correct use of capsule-based powder inhalers increases the effectiveness of the active ingredient. Thanks to the new technology for measuring the flow rate and duration of inhalation, the user receives rapid feedback on the quality of inhalation and can adjust their behavior.
Implantable glucose sensor
The innovative glucose sensor makes it easier for patients to measure their blood glucose. It can be implanted and can remain in the body for a longer period of time. The encapsulation of the sensor due to the foreign body reaction does not interfere with the measurement and reliable results are provided at all times.
Quick, low-cost refractometer
In order to adapt optical systems and lenses precisely to an application, it is necessary to know the material properties and the optical parameters of the lens material. A new method developed by Düsseldorf University of Applied Sciences determines the dispersion (wavelength dependence of the refractive index) using a simplified setup without moving parts and even without a wavelength scan.
5-HMF biopolymers
The present invention relates to polymers from renewable raw materials, as well as monomeric precursors for the production of furan-containing polymers and a production process of both the polymers and the precursors. The 5-HMF derivatives serve as monomers for, among others, biodegradable polyesters, polyamides, polyimines and polyurethanes.
Injection unit for micro injection molding
Thanks to a new type of integration of the shut-off needle into the injection plunger and clever guidance of the plastic melt, the production of miniature and micro components becomes more economical and energy-efficient.
Grooved nozzle
Optimierte Kombi Düse für den isotroperen 3D- Druck. Kombination aus spezifisch geformter Düsenöffnung mit druckbasierter Anlegung an die bestehenden Stränge beim FDM.
Virtual spatial boundaries for robots
Navigating robots safely through spaces - the new technology from Bielefeld University can contribute to this by simply capturing virtual spatial boundaries. The soft-based input of 3D workspaces is thus greatly simplified by augmented reality.
Temperature compensation for semiconductors
The technology of the Ruhr-Universität Bochum is a method for minimizing temperature and tolerance effects in MOS circuits, which can be used in series production for all known analog MOS circuit arrangements. Central parameters such as current consumption, dynamic ranges, gains, 1/f input noise and also the frequency responses can be kept constant.
Phytic acid coating
A new invention from the Hochschule Niederrhein encompasses an environmentally friendly binding agent consisting of alkyl phytic acid oligomers, which can be thermally combined with such substances as epoxy resins (as amine substitutes) and OH-functional binding agents (as crosslinkers).
Climate-neutral steelmaking
Novel raw material input for the production of green steel. In addition to hydrogen, a carbon-containing aerosol is used to produce green steel.
Scalable photodetector
Most optical sensors require an external supply voltage - not so the novel scalable photodetector from the University of Duisburg-Essen. This photodetector can also be processed or manufactured on a foil basis using the MOCVD process. Possible applications include implants without a battery for medical technology.
Greatly improved radar/lidar sensor
Greatly improved distance measurement with radar/lidar sensor through the use of quantum technology. An invention of the University of Paderborn improves radar/lidar systems theoretically up to the resolution limit. Quantum mechanical effects are used here by superimposing several optical signals on a so-called quantum pulse gate (QPG).
ITIH3 - a biomarker for Myasthenia gravis activity
The invention aims at monitoring inter-alpha-trypsin inhibitor heavy chain H3 (ITIH3) in the serum of Myasthenia gravis patients as the first biomarker for the assessment of MG disease activity in clinical routine, e.g. for therapy adjustments. Monitoring can easily be made by quantitative ELISA in routine blood collection. This approach provides objective results, excluding time-of-day dynamics and subjective symptom burden of patients or examiners.
Green Electrodes
Metal free, printable electrode based on an organic compound prepared by polymerization of triaryl amine.
Polymer GRIN
The invention describes a new manufacturing process for GRIN plastic optics, in which extruded films with a defined refractive index gradient are rolled up and sintered. This makes it possible to manufacture lenses with any aperture and adjustable refractive index variation.
Smart power cable monitoring
What is the status of the power cables at the distribution grid level? This information is generally not gathered, since conventional methods such as dissipation factor measurement involve a great deal of effort – and then there are the high costs and power disruption for connected customers.
E-Walker
Walkers are a great help for elderly or temporarily gait-impaired people. However, if the forces are overestimated, the E-Volator from the Ruhr West University of Applied Sciences can lower a stand plate, the person can climb on and then drive electrically and power-saving to their destination.
GCAS
The invention GCAS covers the specific use case of real-time collision avoidance during operation by continuous position exchange across system boundaries of different secondary radar systems. This enables safe operation of multiple unmanned and manned aircraft in a common airspace.
Breath'n'Dream
The advantage is that anesthesiologists have an easy-to-use tool to treat uncooperative or stressed children before anesthesia without sedatives, which can have side effects. There is minimal need to train medical staff to use the new tool. It is cheap to manufacture and without the need for disposable items, which is environmentally friendly.
Wiegand position encoder with Gray code generation
A new technology from the FH Aachen describes a rotation angle sensor for determining the absolute position by means of several Wiegand sensors. The transitions detected by the Wiegand sensors are used in an evaluation circuit to represent the angle of rotation in a Gray code.
EPIC spectrometer
Spectral analysis is used in many areas of measurement technology. But it often requires very large, expensive devices.
Hock rearrangement
The present invention is an environmentally friendly process as a substitute for common synthesis routes for sulfuric acid-free phenol and acetone synthesis.
Optimized chip tests
Reliable microchips, so-called integrated circuits (ICs), must be tested to guarantee the required functionality in later operation. This costs chip manufacturers a lot of time and money. The novel fast chip test (JTAG) with reconfigurable test structures from Hamm-Lippstadt University of Applied Sciences now ensures cost- and time-optimized IC tests.
MultiXQuant
New analytical method for quantification in lightweight materials such as plastics, polymers or refuse-derived fuels using X-ray fluorescence analysis.
Thermoelectric water heat pump
With the new thermoelectric water heat pump, drinking water can be heated to the desired temperatures in an energy-saving manner. For this purpose, the energy is extracted from heating water with a low flow temperature, which has been heated by means of solar thermal energy, for example, and fed to the drinking water to be heated.
Thermoelectric exhaust-air heat pump
With the new heat exhaust pump, the heat of a ventilation system can be efficiently recovered by means of thermoelectric elements. The heated fresh air can also be heated via the temperature of the exhaust air. The exhaust air heat pump is also suitable for cooling buildings.
Wireless water leakage detection
The battery- and wireless sensor system from the University of Paderborn detects water leaks in buildings, heating systems or the water supply. The permanent and maintenance-free monitoring of bathroom seals, washing machines, basement rooms as well as any kind of water-bearing pipes can be realized reliably and cost-effectively.
Synthetic Cytokine Receptors
Synthetic cytokine receptors (SyCyRs) enable defined background-free cellular responses through addition of synthetic ligands. The system allows the engineering of highly specific amplification or eradication switches for recombinant cells.
Optimized radial compressor
Moving blades can be used in compressors, superchargers and exhaust gas turbochargers to increase overall efficiency by extending the operating range. This new technology was developed at the University of Duisburg-Essen and can be used across all industries.
Efficient fuel cells
The efficiency in fuel cells can be increased by using the waste heat of the fuel cell and the pressure energy of the hydrogen tanks. A system module consisting of a turbine with generator and a heat exchanger can significantly increase the overall efficiency of the process in the fuel cell.
Optical magnetometer
The invention can optically measure magnetic fields with high sensitivity and can be used, among other things, for soil investigations, navigation systems or material investigations. The method from the University of Siegen can also be integrated into existing fluorescence microscopes.
Total Toe – The foot expander
The "Total Toe", a training device for the toe flexor muscles, can reduce foot amputations for diabetics. Regular training has been shown to counteract muscle regression and reduce peak pressure under the foot - reducing problematic ulcerations and resulting foot amputations.
Movement optimization training tool
In order to optimize movement execution, athletes need feedback on their own movement progress. This technology can increase both effectiveness and efficiency through an extended reality (XR)-based approach using real-time feedback.
Self-Assembling Oxide Catalyst for Electrochemical Water Splitting
Electrocatalytic material for oxygen evolution reaction (OER) in alkaline solutions. The main purpose is to make the Hydrogen production more effective. The catalyst is based on perovskites with high activity (industry comparable once based on metals). In the same time (and in contrast to all other perovskite-based catalysts) it is stable at industrial conditions.
Monitoring of hemophilia
The invention relates to PD1 as a biomarker for monitoring immune tolerance of coagulation factor VIII treatment of hemophilia A patients.
Vector spectrometer
An improvement in high-resolution gigahertz and terahertz spectroscopy, now enables sensitive measurements of high-frequency signals over a wide spectral range. The application areas for this technology are in chemical analysis as well as quality control: The sensitivity in the measurement of analysis samples with high-frequency signals can thus be significantly increased.
Chromosomal rearrangements in lung cancer
The invention allows to predict tumor responsiveness to FGFR inhibitor treatment, hence, it can serve as a diagnostic tool to guide personalized precision medicine in cancer treatment.
SafeGuard-BR system
The lockable intubation adapter system allows hygienic, protected performance of intensive-care examinations without releasing infectious aerosol particles or droplets into the ambient atmosphere.
Selective ion storage
The measurement of molecular spectra is important for the chemical or pharmaceutical industry. The new method from the University of Cologne is suitable for the acquisition of any kind of spectra of ion species such as rotational, vibrational, Ro-vibrational, electronic spectra. The composition of the spin states of electrons and nuclei can also be determined. This opens up completely new areas of application.
Neurostimulation with light
The stimulation of nerve cells with electrical or optical impulses is a field of research with a multitude of new applications in medicine. In the future, optogenetics will be used to research the healing possibilities of neurodegenerative diseases or traumatic injuries by stimulating photosensitized nerve cells.
String Locks
The tuning stability of stringed instruments - e.g. guitars - depends, among other things, on the fixation of the two string ends. The underlying invention optimizes this by using small clamping components ("bullets") whose use does not require any modification measures and is always reversible. These clamping components thus lead to increased tuning stability in stringed instruments and at the same time to less (time-) consuming string changes. The bullets are used either on the machine head or on the bridge.
Optical power supply
Quantum optical detectors are one of the markets of the future, but these detectors need to be heavily cooled. The novel system uses optical fibers for the energy supply, thus avoiding thermal bridges that occur with the usual use of copper lines. The photodiode then generates the required operating voltage for the detector from the light.
Improved satellite navigation
Position determination is of great commercial benefit for motor vehicles in logistics or agricultural technology, among others. A multi-antenna receiver system designed as a ballast at Münster University of Applied Sciences can enable high-precision position determination with conventional GNSS receivers down to a few centimeters.
Wiegand position encoder
Rotary encoders or incremental encoders are used in a wide range of industrial applications. An invention from the FH Aachen makes it possible to measure the angle of rotation or the rotational speed with the aid of a Wiegand sensor, which can be designed as a relative or absolute sensor, and a rotor that can be manufactured at low cost.
Improved "pump and probe" measurements
Optical pump-probe experiments are often used in spectroscopy and metrology. A new technology from the Ruhr-Universität Bochum allows to electrically control the sequences of excitation and interrogation pulses or the delay time between them. The advantage: No moving parts are required and no intervention in the laser resonator.
Amipysurf
An Invention for prevention of bacterial infection by applying an antimicrobial latex for a surface coating that is mechanically stabilized by chemical or photochemical crosslinking
PLL frequency acquisition
The new and ASIC available PLL circuit of the University of Paderborn can be used in communications or control and measurement technology, especially where a permanent slow sine signal is used e.g. Bang-bang PLL, Hogge PLL, Baud rate CDR, Optical transceivers circuits.
Solar capsule
Solar energy is generated from solar panels or photovoltaic systems in solar farms or on house roofs. An invention by the University of Siegen based on a dye-sensitized solar cell (DSSC) now makes it possible to manufacture affordable thin-film solar cells that can be applied to any surface like paint.
Continuous 3D printing
In order to be able to use 3D printing systems economically and efficiently in series production, the available installation space in the 3D printer must be used optimally for each print or production batch. Thanks to an inclined arrangement of the build platform, the process offers the opportunity to economically mass-produce components despite a high variety of geometries. This is necessary, for example, for medical technology components that have to be adapted to individual structures or body geometry (e.g. dental orthopedics, sports equipment, etc.) and may also have to be fed continuously without batch operation.
Quantum Dot Arrays
Nanostructures are suitable for the fabrication of optoelectronic devices, but their fabrication is costly. Their utility, however, is immense: mode profiles can be created in a direct way, for example, to "attract" lasers or to adjust densities for single quantum dot applications such as single photon sources.
Smart grid expansion
Intelligent power grids can monitor and regulate themselves independently. A new process from the University of Wuppertal makes it possible to stabilize the voltage in grids by installing control units, as well as avoiding overloads.
Photoacoustic gas sensor
Gas sensors are used for the detection of gaseous substances. Resistive measurement methods are often used, but their signal values often exhibit drift due to aging or lose selectivity. A new type of photoacoustic gas sensor (PAS) from the Technical University of Dortmund is different: it detects target gases very precisely and selectively.
Detecting ionizing radiation
Ionizing radiation is harmful to humans and the environment even in the smallest quantities. Therefore, radioactive materials must be continuously monitored in hospitals, mines or reprocessing plants. A novel semiconductor sensor can analyze ionizing radiation in an integrated microfluidic system (in-situ).
Laser absorption spectroscopy
The new method from TU Dotmund uses laser absorption spectroscopy to monitor air quality in order to measure trace gases present, such as methane or CO2. The improved intra-cavity absorption spectroscopy allows the application in measurement technology, industrial process monitoring as well as safety engineering.
Faster MRI examinations
Magnetic resonance imaging (MRI) is an expensive diagnostic imaging examination. A new method developed by the University of Duisburg-Essen significantly shortens MRI examination times by synthetically generating STIR sequences without the otherwise time-consuming STIR scans.
Optical Strain Gauge
The novel and all-optical strain measurement method is highly accurate and cost-effective. The strain is determined by means of an optical fiber-based purely optical method and thus also enables use in harsh application fields, such as explosion-proof areas or where disturbing pulsating magnetic fields interfere with conventional strain measurement sensors.
Diamond Schottky LED
LEDs are used today in a wide variety of applications, including lighting, data transmission, and biological processes. However, the commonly used LED materials are unsuitable for many applications. By using doped diamond, these LEDs can be designed specifically for high temperatures or pressures and especially for applications with special requirements, e.g. in optical metrology.
Vim3 and Mxi-2 antibodies
The invention relates to Vimentin3 and Mxi-2 antibodies found for the non-invasive diagnosis of kidney tumors. These antibodies can make a clear differentiation of oncocytoma and RCC types and allow targeted therapeutic measurements.
Substitute for LIDAR sensors
Optical components like photodiodes have a variety of uses in sensors and telecommunications technology. Even with time-of-flight sensors, the light reflected by objects has to be converted into electrical signals in order to compute the distance or speed of said objects.
Interference filter
Many optical systems, devices and sensors use the principle of interference - an essential factor in the development and optimization of thin-film devices.
OptoRyR
Light-induced opening of the Ryanodine receptor for use as a scalable system in drug screening.
Arylsulfatase A knock-out mice
These mice can be used as a model to study metachromatic leukodystrophy, which is caused by a loss of arylsulfatase A function and consequently by sulfatide accumulation.
Gfi1(1b/1b) and Gfi1(P2A/P2A) Mice
The Snail/Gfi1 (SNAG) family of zinc finger proteins is a group of transcriptional repressors. Gfi1 is a transcriptional repressor being expressed in the hematopoietic and nervous system. Loss of function leads to severe defects in hematopoiesis and inner ear development.
Uveal Melanoma Cell Line with monosomy 3
Uveal melanoma is the most common intraocular malignancy. Approximately 50% of uveal melanoma patients die of metastases, which mainly arise from primary tumors with loss of an entire chromosome 3.
Induced Pluripotent Stem Cells (iPSC) of Patients with Heart Diseases
The iPSCs were generated from reprogrammed human dermal fibroblasts. The fibroblasts were derived from patients with heart diseases of distinct genetic background. Controls of healthy volunteers are also available.
Antibody against extracellular matrix (ECM)-components
The polyclonal antibodies are directed against the following proteins of the extracellular matrix: laminin 1, laminin 5, nidogen 1, nidogen 2, cartilage oligomeric matrix protein (COMP).
Antibody against Amyloid-beta phosphorylated at Ser 8 and 26
The antibodies are directed against specific phosphorylation sites of Amyloid-beta at serine 8 or at serine 26, respectively. Forms of Amyloid beta phosphorylated at these serine residue have increased propensity to form toxic aggregates as compared to non-phosphorylated species.
Antibody against the ABD domain of Nesprin-2 Giant
The antibody is directed against the aminoterminal actin-binding domain (ABD) of human Nesprin-2 Giant. Nesprin 2 Giant, also referred to as Enaptin and NUANCE, is involved in the maintenance of nuclear organization and structural integrity.
Antibody against Amyloid-beta nitrated at Tyr10
The antibody is directed against Amyloid-beta, which is nitrated at the tyrosine on position 10. This nitration of tyrosine enhances Amyloid-beta aggregation and plaque-formation.
Novel therapy for Metachromatic Leukodystrophy
The technology relates to a variant of the enzyme arylsulphatase A characterised by increased blood-brain barrier permeability, catalytic activity and half-life, and which is suitable for the treatment of metachromatic leukodystrophy by an enzyme replacement therapy.
Compensating for Leakage current
Efficient charging of traction batteries is a key technology for the success of electric vehicles on the market. To this end, concepts for transformerless on-board chargers are currently being increasingly considered. Interfering high leakage currents to ground can be prevented or compensated for by this invention.
Optimized Amplifier Circuit
Shunt current measurement techniques are used in electric cars and in the charging stations. Special control of the circuit allows amplifiers to be ramped up to the operating point very quickly, safely and reliably. The amplification factor can be adjusted over three orders of magnitude.
Submerged Bioprinting
The present invention allows to print the conduits submerged in non-miscible solvents of high density, such as fluorocarbons (e.g. C12F27N), that support the printed structure while it is being generated resulting in superior performance in relation to other methods. Viable cells 24 h after the printing process, as well as after 21 days in culture.
3D-TAM (Tumour Angiogenesis Model)
This model can be used to analyse tumour groth, tumour angiogenesis and therapeutic effects on the 3D-printed cell model. No animal tissue is needed. Therefore, this 3D-printed Tumour Model represents an ideal in-vitro-prescreening system for testing pharmaceuticals and diagnostics and might be able to circumvent or at least reduce the number of animal tests in drug development.
Microwave thermograph
The new method for microwave thermography uses a commercially available HD optical camera and an indicator plate to convert the microwaves into a high-resolution, digital field distribution. The developed indicator plate allows microwave thermography between 1 GHz and 300 GHz.
Dummy foot
The invention uses an individualized foot dummy to provide the possibility of examining the lower leg orthosis in order to enable adequate immobilization. To achieve this, the supporting leg is scanned and then additively manufactured in individual parts.
CMOS biosensors
Production process for a highly sensitive biosensor made from a crossed nanowire-structure field-effect transistor. The cost effective CMOS compatible production process allows for e.g. biosignal monitoring of molecules like c-reactive protein (CRP), cardiac troponin (cTnI), electrogenic cells, or peptides such as amyloid-beta.
Modular charging station
This modular charging station for small, battery-operated devices like electric toothbrushes enables low-wear charging of batteries and reduces messy cabling.
Smart charging for electric vehicles
There is a growing trend for electric vehicles. Their drive batteries require charging at high power from the available AC power grid. Three-phase on-board chargers (OBCs) are used for this purpose at high power outputs of at least 11 KW.
Lab-on-a-Chip-System
Magnetic particles are often used to transport and/or separate biomolecules such as DNA or proteins. These particles have biochemically functionalized surfaces and are used as markers in analytical biotechnology and medical technology.
New Cryptophycins for ADC and SMDC
The present invention combines new synthetic ways to new Cryptophycin derivatives with alternative conjugation possibilites and pico-molar cytotoxicies, for ADC and SMDC synthesis.
Hydrophobic Phytic Acid Conversion
The innovation presented here concerns the production and use of hydrophobic phytic acid derivatives as an environmentally friendly alternative to conventional phosphate corrosion protection pre-treatments for steel.
Lock-In Amplifier
Lock-In amplifiers are firmly anchored in everyday research. They offer excellent noise suppression for repeating signals. The degree of suppression, however, depends critically on the low-pass filter at the end of the signal processing chain.
Window for high temperatures
For the monitoring of highly complex processes in closed reaction vessels, it would often be desirable to be able to observe the process and monitor it by means of optical measuring systems.
Effective hydrogen production
At the Ruhr University Bochum an effective method was developed with which the coating of an electrode can be achieved with high long-term stability, especially during electrolysis such as alkaline water splitting. Due to the coating of the electrode surface with catalytically active material, a significant reduction in the required cell voltage is achieved.
Nano-BioTransporter
Cancer is one of the main causes of death worldwide. One of the newer therapeutic approaches is photodynamic therapy (PDT), a treatment that uses a photosensitizing chemical substance, a particular type of light and oxygen.
Cholinergic activity enhancer
Acetylcholine (ACh) is an essential neurotransmitter with a major function in the central and peripheral nervous system. Furthermore, ACh plays a crucial role in the autonomic nervous system stimulating preganglionic parasympathetic and sympathetic nerve fibres and postganglionic parasympathetic neurons.
Spray freeze-drying
Spray freeze-drying combines the advantageous properties of the well-established techniques spray drying and freeze-drying.
MRGPRX4 Receptor Agonists and Antagonists
G protein-coupled receptors (GPCRs) are the largest group of membrane receptor proteins and represent the most successful targets of drug therapy.
FlexOxy
With extracorporeal membrane oxygenation, the physician only has oxygenators in a few different sizes. A suitable volume would be particularly important for infants and small children in order to relieve the blood circulation.
Optically switched resonant-tunneling diode
Resonant-tunneling diodes are semiconductor components that, due to the quantum mechanical effect of the tunnel, have a current-voltage characteristic with a negative differential resistance.
High-Redshift BODIPY Dyes
Fluorescent molecules are widely used in bioimaging and medicinal applications for several decades due to their high sensitivity and easy visibility.
Plasma Biocatalysis
Enzymatic reactions offer the possibility to synthesize new molecules with high selectivity and turnover.
Extracorporeal apheresis to treat preeclampsia
Pre-eclampsia is caused by an imbalance between the pro-angiogenic factors VEGF and PIGF and the anti-angiogenic factor sFlt-1, because sFlt-1 binds both factors. This binding leads to the inactivation of VEGF and PIGF. The present invention relates to a method by which sFlt-1 is eliminated from blood in an apheresis procedure by passing the blood over a column containing immobilised moVEGF165 or scVEGF165. Simultaneously with sFlt-1 binding, sFlt-1-bound VEGF and PIGF are released so that the angiogenic balance, essential for fetal development, is restored after the return of the two pro-angiogenic factors.
Color flop effects without interference pigments
It is an innovative, cost-effective application method for the creation of color flop effects by means of effect pigments without costly interference pigments.
Determination of the degree of curing of a coating
The method is based on the fact that the polymer network in a cured coating is denser than in a coating that is less cured. It concerns a method by which chemical cross-linking and thus suitability for further processing can be determined for a system of coatings.
Intelligent charging for electric vehicles
Short charging times are essential for the acceptance of battery-powered vehicles. As a result, three-phase on-board chargers are increasingly being installed in electric vehicles as they significantly reduce charging times compared to single-phase charging circuits.
NoFlameSty
Halogen-free polystyrenes that contain flame-retardant components in the polymer chain. These styrene copolymers can be produced synthetically in a batch process using inexpensive raw materials and are characterized by self-extinguishing fire behaviour without the addition of flame retardants. The resulting polymers are completely colorless and odorless and can be extruded and/or foamed using conventional processing methods. If necessary, the fire behaviour can be further optimized by adding flame retardants, depending on the application.
On the trail of plasma
Plasmas are used in a wide range of technical applications, including semiconductor technology. Plasma etching and plasma-induced material deposition are used to remove functional layers in a structured manner or to selectively generate surface hardening, cleaning and activation on the target surface.
Oil float
Previous solutions or approaches to the elimination of oil spills on water surfaces consist either of actively working pumps, chemicals or materials that absorb the oil and then have to be cleaned or disposed of.
MRGX2 Receptor Antagonists
G protein-coupled receptors (GPCRs) are the largest group of membrane receptor proteins and represent the most successful targets of drug therapy.
DC-DC resonant converter
Flexible chargers for batteries (especially in the field of e-mobility), fuel cell applications or flexible photovoltaic battery combinations all contain switch-mode power supplies with DC converters, DC-DC converters in short.
Method for current measurement in half-bridge topologies
A number of different instrument transformers are used to determine voltage and current in regulated power electronics. Current measurement becomes more and more difficult with increasing current intensity, especially since the switching frequencies increase due to the use of modern (e.g. GaN) transistors and parasitic properties of the sensors must be minimized.
GridMaximizer
The electrical power grid is undergoing a major transformation. Increasing numbers of decentralized feeders have been added in recent years and, in the future, there will be a large number of charging stations for electric vehicles that temporarily draw a large amount of electrical power from the power grid.
Future Display Technology
The presented technology is a two dimensional optical waveguide with very low attenuation.
dualMode-Radio
Most current radio transmission techniques use locally generated signals for the demodulation of the received signals. The electronic devices like synthesizers and local oscillators needed for the demodulation are expensive and require much space.
NMDAR Antagonists as new Antidiabetic Medication
According to the International Diabetes Federation (IDF), diabetes affects close to 400 million people worldwide and caused 500 billion Euros in health expenditure in 2013.