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Weed infestations cause considerable crop yield losses worldwide. C4 weeds like Black-Grass, Cleavers, Green foxtail, Kochia and Barnyard Grass reduce yields of important C3 cereals such as rice, wheat, barley and oat. For example, Barnyard Grass, the most important weed species in rice, which is now found in over 60 countries ranging from North America to South Asia provokes yield losses of up to 70 %. Similarly, Black-Grass has become a severe threat for global food production causing yield losses of 5 to 50 % already in Western Europe. Besides, the resistance to existing herbicides is increasing - provoking the need for alternative weed killers.
Selective herbicides against C4 plants would be of outmost importance for the agribusiness and a major turning point in the control of the worst weeds in the world.
Scientists of the Heinrich Heine University Duesseldorf succeeded in finding a sophisticated way to sustainably and selectively inhibit C4 type phosphoenolpyruvate (PEP) carboxylase, an enzyme that has an important role in CO2 fixation and exists in all variants of C4 metabolism.
Keywords: C4, herbicide, selective, weed, crop, rice, wheat, black-grass, Alopecurus, Echinochloa, Gallium, resistance, small molecules
In contrast to existing approaches the small molecules regarding the present invention do not bind to C3 type PEP carboxylases although these enzymes show sequence identity of up to 95% with the C4 enzyme. Hence they do not affect the C3 metabolism. Consequently, C3 plants prosper well, C4 plants do not.
The present invention provides compounds being capable of binding selectively to a specific site of PEP carboxylases from a C4 plant and thereby inhibiting this enzyme.
On behalf of the Heinrich Heine University Duesseldorf, PROvendis offers access to rights for commercial use as well as the opportunity for further co-development.
In case of interest we are pleased to inform you about the current patent status.