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Preventing prostheses- and dental implant-associated infection using antimicrobial peptides of cartilage-specific CLEC3A
Bacterial infection is one of the most frequent complications in joint replacement and dental implant surgery. The incidence of septic arthritis following total joint arthroplasty is approximately 2%, leading to massive health problems and considerable cost to the national economy. Dental implant inflammation is another frequent condition with serious oral health and economic consequences. A new approach to reduce such infections is antimicrobial coating of prostheses and implants. Major drawbacks of such an approach are that peptides and other substances from exogenous sources are often cytotoxic and may cause an activation of the immune response.
Keywords: Antimikrobiell, Prothese, Implantat, Chirurgie, Infektion, Oberflächenbeschichtung, Antimicrobial, prothesis, implant, surgery, infection, surface Coating
Rearchers of the Medical Faculty of the University of Cologne have demonstrated that peptides of the cartilage-specific CLEC3A kill both Gram-positive and Gram-negative nosocomial bacteria (Figure A). Furthermore, coating these antimicrobial peptides on titanium substrates significantly reduces bacterial adhesion on titanium substrates (Figure B). Coating of prostheses and dental implants with CLEC3A-derived antimicrobial peptides could therefore be an effective way of preventing infection without cytotoxicity and immunogenicity issues.
The invention is offered for licensing and further co development in collaboration with the researchers.
- Potent antibiotic activity against both Gram-positive and Gram-negative nosocomial Bacteria
- No immunogenicity due to the protein`s natural expression in cartilage
- No cytotoxicity against human cell
- Suitable for surface coating of prostheses and dental implants
The researchers have shown that even high concentrations of CLEC3A-derived peptides show no cytotoxicity against primary human chondrocytes. In case of interest we will be pleased to inform you about the patent status. In case of interest we will be pleased to inform you about the patent Status.
Manuscript in preparation.