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Peripheral nerve damage is a common cause of considerable functional morbidity, and healthcare expenditure. Surgery can be done in case of a peripheral nerve cut or rupture but a large section of injuries however is unsuitable for primary repair, and standard clinical management results in inadequate sensory and motor restoration in the majority of cases, despite the rigorous application of complex microsurgical tech-niques.
In general, injured peripheral nervous tissue possesses the capacity to regenerate severed axons and therefore the ability for repair. Mechanisms of so-called neuroregeneration may include generation of new glia, extension of axons, re-myelination or restoration of functional synapses. However, the ability for neuroregeneration differs strongly between the peripheral nervous system (PNS) and the central nervous system (CNS). However, although injured axons of the peripheral nervous system show generally greater potential for intrinsic axonal regrowth, functional regeneration is often limited, mainly due to a decline in neurotrophic support from Schwann cells over time and axonal misguidance.
These aspects become particularly evident in cases of long distance regeneration, for example after sciatic nerve injury in legs or median nerve damage in arms. Therefore, the development of novel therapeutic measures aiming to accelerate axon regeneration and thereby improving functional recovery is highly desirable.
It was found by the inventors of the present invention that the natural product parthenolide and its derivatives facilitate the axonal growth and guidance of injured peripheral nerves in cell culture and most significantly also in vivo. The inventors demonstrate that the intraneural injection of parthenolide at the regenerating nerve results in an improved functional motor recovery as well as in an improved sensory functional recovery.
On behalf of University Düsseldorf, PROvendis offers this opportunity for licensing or co-development.
A priority application has been filed.