It is of use in several research applications, including ELISA, WB, IP, IHC, fluorescence microscopy and flow cytometry. In addition, the monoclonal antibody (mAB) is suitable for use as a diagnostic tool for the detection of inflammatory disorders (e.g. sepsis, multiple sclerosis) as well as for solid tumors, and applies for therapy monitoring of the latter.
Cancer patient data have been generated that support the diagnostic potential.
A German patent application has been filed. On behalf of the University of Duisburg-Essen, PROvendis offers access to the antibody for commercial use.
Singer BB (2005): CEACAM1. UCSD-Nature Molecule Pages (doi:10 1038/mp a003597 01)
Muturi HT et al. (2013): Tumor and Endothelial Cell-Derived Microvesicles Carry Distinct CEACAMs and Influence T-Cell Behavior. PLoS One (doi: 10.1371/journal.pone.0074654)
Klaile E et al. (2013): Carcinoembryonic antigen (CEA)-related cell adhesion molecules are co-expressed in the human lung and their expression can be modulated in bronchial epithelial cells by non-typable Haemophilus influenzae, Moraxella catarrhalis, TLR3, and type I and II interferons. Respiratory Research (doi: 10.1186/1465-9921-14-85)