Already after 7 days of treatment in serum-free medium, the resulting cell population showed markers characteristic for hepatic differentiation like albumin expression.
Bile acids exert their function via the farnesoid X receptor and the G protein-coupled bile acid receptor 1 (TGR5). Cells obtained by the protocol may be used in a tissue replacement therapy.
On behalf of University Düsseldorf, PROvendis offers this opportunity for licensing or co-development.
A priority application has been filed.
Kordes C & Häussinger D. Hepatic stem cell niches. J Clin Invest. 2013;123(5):1874–1880.
Kordes C, Sawitza I, Götze S, Herebian D, Häussinger D. Hepatic stellate cells contribute to progenitor cells and liver regeneration. J Clin Invest. 2014;124:5503-5515.