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Bile acids aid liver repair - Bile acids induce hepatic diffentiation



Ref.-Nr. 4247

Hepatic failure is a terminal picture of many liver diseases such as hepatic steatosis, liver cirrhosis and hepatocellular carcinoma, and is treated by liver transplantation, but a lack of donor organs is a worldwide problem. Thus, there is a demand for a means for safe and rapid liver regeneration for small grafts. One possibility would be the generation of a patient’s own liver tissue using isolated stem cells.

Currently various protocols for directed hepatic differentiation of stem cells have been developed in the prior art as alternatives for large scale hepatocyte production. For instance, embryonic stem cells can be grown in unlimited numbers and differentiate into functional hepatocyte-like cells in culture. Maintenance, growth and differentiation, however, are time consuming and expensive. Thus, there is a need for quick reliable protocols to reprogram patient’s own somatic cells into liver cells.

The inventors found that mesenchymal stem cells can be reprogrammed into hepatocytes by treatment with bile acids.

Already after 7 days of treatment in serum-free medium, the resulting cell population showed markers characteristic for hepatic differentiation like albumin expression.

Bile acids exert their function via the farnesoid X receptor and the G protein-coupled bile acid receptor 1 (TGR5). Cells obtained by the protocol may be used in a tissue replacement therapy.

Commercial Opportunities

On behalf of University Düsseldorf, PROvendis offers this opportunity for licensing or co-development.

Current Status

A priority application has been filed.

Relevant Publications

Kordes C & Häussinger D. Hepatic stem cell niches. J Clin Invest. 2013;123(5):1874–1880.
Kordes C, Sawitza I, Götze S, Herebian D, Häussinger D. Hepatic stellate cells contribute to progenitor cells and liver regeneration. J Clin Invest. 2014;124:5503-5515.

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Prof. Dr. Frank Entschladen

Prof. Dr. Frank Entschladen

Dieses Angebot


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