In this context, the invention comprises a novel class of iron carbonyl complexes, which release their CO load only after enzymatic activation. The powerful CO-releasing properties and the structural variability form a promising basis for the development of safe and pharmacologically useful CO-releasing molecules (CORMs).
Biological tests (using different cell lines) have proven the chemical concept and confirmed the intracellular CO-release. Moreover, structural variation revealed pronounced structure-activity relationships. The clear-cut chemical concept and the developed synthetic schemes (opening short and efficient entries both to compound libraries and to larger amounts of individual complexes) provide excellent pre-conditions for structural optimization. Some initial results have been published.
CO-releasing molecules have the potential to become an important new class of drugs in the future. First generation CORMs reported in the literature do not meet the required pharmacological properties. However, the enzyme-triggered compounds (representing prodrugs) have a unique potential. The delivery of small amounts of CO to tissues can widen blood vessels, increase blood flow, prevent unwanted blood clotting, reduce inflammation and even suppress immune responses and the activity of cells and macrophages which attack transplanted organs.
- Acyl-oxydiene-Fe(CO)3 complex¬es are an innovative class of ET-CORMs allowing for the first time a controlled intracellular and potentially tissue-specific CO-release
- First water-soluble enzyme-triggered CO-releasing molecules
- ET-CORMs open new perspectives for the prevention and cure of diseases involving inflammatory, infectious, thrombotic or proliferative processes
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