In order to further improve the bioactivity of promising compounds, researchers of the TU Dortmund University have focused on optimizing the physico-chemical properties that are important for permeability, since M. tuberculosis shows an unusual thick and impermeable cell wall.
The technology is offered for licensing and further therapeutic development.
- Novel class of compounds that inhibit a novel target with potential to overcome resistance problems of M. tuberculosis to other drugs
- Viability of infected macrophages is not affected
- Increased bioactivity by optimized permeability through the cell wall of M. tuberculosis
The researcher are preparing the further development towards mice studies to confirm in vivo efficacy, as well as ADME‑Tox studies. In case of interest we are pleased to inform you about the patent status.
Koch, O., et al. (2013) Identification of M. tuberculosis thioredoxin reductase inhibitors based on high-throughput docking using constraints J. Med. Chem. 56(12): 4849-59.