The invented substance and protocol are of high interest for any supplier or company in the field of microscopy and imaging techniques. The unique selling proposition is that the herewith offered invention constitutes the sole methodology optical clearing of biological samples without use of harmful chemicals combined with high quality fluorescence preservation.
The invented substance and protocol is routinely used by the inventors and has thus been shown to be robust for general laboratory usage.
On behalf of the University of Duisburg and Essen, PROvendis offers access to rights for commercial use as well as the opportunity for further co-development, e.g. of a kit. In case of interest we will be pleased to inform you about the patent status.
Richardson DS & Lichtman JW. Clarifying tissue clearing. Cell 2015; 162(2): 246-57.
Ertürk A, et al. Three-dimensional imaging of solvent-cleared organs using 3DISCO. Nat. Protoc. 2012; 7(11): 1983-95.
Hama H, et al. Scale: a chemical approach for fluorescence imaging and reconstruction of transparent mouse brain. Nat. Neurosci. 2011; 14(11): 1481-8.