P2Y 12-receptor antagonist - Novel antagonists of the P2Y12-receptor with antithrombotic effect

Ref.-Nr. 1526

Keywords: P2Y 12-receptor antagonist, antithombotic effect, platelet aggregation, neuroinflammatory and neurodegenerative diseases

The P2Y12-receptor on blood platelets is the target of known antithrombotic drugs (e.g. clopidogrel). The receptor is therefore validated for this therapeutic use. Furthermore, the P2Y12-receptor is expressed in certain parts of the brain, which opens new routes for the treatment of neuroinflammatory and neurodegenerative diseases. This invention provides novel antagonists of the P2Y12-receptor. The disclosed novel compounds show reversible and selective binding to the P2Y12-receptor. The molecules do not require bioactivation. Further the patent application discloses synthesis of the compounds with optimised product yield.

Vorteile

  • Innovative group of compounds for a validated target
  • No bioactivation for faster onset of action
  • Reversible binding to the receptor
  • Small molecules for inexpensive production process

Kommerzielle Anwendung

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Aktueller Stand

Patent applications for the invention have been filed in Europe and North America.

Eine Erfindung der Uni Bonn.

Dr. Andreas Wagener

aw@provendis.info
+49 208 9410538