Anoctamin-6/Tmem16f -deficient mice
Deletion of Ano6 in mice results in reduced skeleton size and skeletal deformities due to impaired ossification, whereas proliferation and differentiation of chondrocytes is not affected.
Complete deletion of the Ano6 gene
Research, drug development
Ehlen, H.W., et al. (2013): Inactivation of anoctamin-6/Tmem16f, a regulator of phosphatidylserine scrambling in osteoblasts, leads to decreased mineral deposition in skeletal tissues. J. Bone Miner.Res. 28(2): 246-59.