The antibody is directed against Amyloid-beta, which is nitrated at the tyrosine on position 10. This nitration of tyrosine enhances Amyloid-beta aggregation and plaque-formation.

Immunogen/Epitope
A peptide close to the aminoterminal end of human Amyloid-beta: FRHDSG(nitrated-Y)EVHHQ

Antibody-Type
Mouse monoclonal

Usage
Diagnostic, Research

Tested Applications
Western Blot, Immunohistochemistry, Immunoprecipitation, ELISA

Reference
Kummer, M. P., et al. (2011) Nitration of tyrosine 10 critically enhances Amyloid-beta aggregation and plaque formation. Neuron 71: 833-844.