The antibody is directed against the aminoterminal actin-binding domain (ABD) of human Nesprin-2 Giant. Nesprin 2 Giant, also referred to as Enaptin and NUANCE, is involved in the maintenance of nuclear organization and structural integrity.

Immunogen/Epitope
Amino acids 1-459 of human Nesprin-2 Giant

Antibody-Type
Mouse monoclonal

Usage
Diagnostic, Research

Tested Applications
Electron microscopy, Immunocytochemistry, Immunohistochemistry, Western Blot, Immunoprecipitation

Reference
Libotte, T., et al. (2005) Lamin A/C–dependent localization of Nesprin-2, a giant scaffolder at the nuclear envelope. Mol. Biol. Cell 16, 3411-3424.