The test system as well as novel BMP-mimetic compounds are offered for licensing and further biotechnological and/or therapeutic development.
- Unique, innovative, stem cell-based assay for the identification of BMP-mimetic agents
- Ligand-independent BMP-mimetic compounds with novel mode-of-action
Ready-to-screen assay format for up to 50,000 compounds comprising libraries. In addition, several functionally validated BMP mimetic compounds have been identified, including first profiling of structure-activity relationships by means of medicinal chemistry. A European priority application is pending.
Feng, L., et al. (2016) Discovery of a small-molecule BMP sensitizer for human embryonic stem cell differentiation. Cell Reports 15: 2063-75.
Ali, I.H. & Brazil, D.P. (2014) Bone morphogenetic proteins and their antagonists: current and emerging clinical uses. British Journal of Pharmacology 171: 3620-32.