The described anti-TOSO CAR T cells have a strongly improved selectivity of target cell killing. The reduction of adverse effects on normal cells provides a competitive advantage against all other CAR T cell approaches that are currently on the market.
Functional data have been generated in cell-based assays with allogenic and autologous CAR T cells showing selectivity and efficiency of target cell killing activity (original data available on a confidential basis).
A European patent application and a US patent application are pending.
On behalf of the University of Cologne, PROvendis offers a patent license as well as a research collaboration with licensing option.
Faitschuk, E., et al. (2016) Chimeric antigen receptor T cells targeting Fc µ receptor selectively eliminate CLL cells while sparing healthy B cells. Blood 128: 1711-1722.
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