Rearchers of the Medical Faculty of the University of Cologne have demonstrated that peptides of the cartilage-specific CLEC3A kill both Gram-positive and Gram-negative nosocomial bacteria (Figure A). Furthermore, coating these antimicrobial peptides on titanium substrates significantly reduces bacterial adhesion on titanium substrates (Figure B). Coating of prostheses and dental implants with CLEC3A-derived antimicrobial peptides could therefore be an effective way of preventing infection without cytotoxicity and immunogenicity issues.
The invention is offered for licensing and further co development in collaboration with the researchers.
- Potent antibiotic activity against both Gram-positive and Gram-negative nosocomial Bacteria
- No immunogenicity due to the protein`s natural expression in cartilage
- No cytotoxicity against human cell
- Suitable for surface coating of prostheses and dental implants
The researchers have shown that even high concentrations of CLEC3A-derived peptides show no cytotoxicity against primary human chondrocytes. In case of interest we will be pleased to inform you about the patent status. In case of interest we will be pleased to inform you about the patent Status.
Manuscript in preparation.