TiDEC addresses this severe limitation. TiDEC exploits the stability of oligopyrimidine adapter sequences to a large variety of reaction conditions, and reagents such as transition metal catalysts and acidic organocatalysts. Thus, TiDEC enables efficient access to diverse heterocyclic structures conjugated to oligopyrimidine sequences from simple and readily available starting materials by a large variety of catalysts. These oligonucleotide-heterocycle conjugates are readily ligated to coding DNA sequences. Combinatorial mix-and-split synthesis yielded a proof-of-concept screening library counting 15,000 molecules: tiDEL, oligothymidine-initiated DNA-Encoded Library. The tiDEL is based on biologically relevant heterocyclic core structures that are found in natural products, drug candidates and approved drugs. It is currently expanded to diverse classes of drug-like structures comprising heterocycles and macrocycles.
The TIDEC platform technology and the tiDEL screening library are offered to pharma-companies, biotech companies, and non-profit organizations for drug identification and development programs.
On behalf of the Technical University of Dortmund, PROvendis offers a patent license as well as a research collaboration with licensing option.
- Handling of large encoded compound screening libraries: tiDELs
- Access to biologically relevant chemical space that is inaccessible by conventional DNA-encoded libraries: encoded natural product- and drug-derived compound classes
- Efficient and rapid screening on target proteins by selection
- Extremely reduced costs in comparison to conventional high-throughput Screening
- Accelerated identification of starting points for drug development programs
TiDEC is currently used to synthesize DNA-encoded screening libraries (tiDELs), and these are provided for target-based screening on disease-relevant proteins. In case of interest we are pleased to inform you about the patent status.