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Photocage Cap for mRNAs
Almost all eukaryotic messenger RNAs (mRNAs) are modified at their 5'-ends by a cap that is synthesised by addition of a 7-methylguanosine attached via a 5'-5' triphosphate bridge to the first transcribed nucleotide of the mRNA chain.
Industrial filter bags with catalytic properties are state of the art. They consist of a multi-layer fabric, containing catalytic particle in the intermediate space. Due to this construction, there is a huge pressure lost and cost for an additional fabric layer.
The present invention "Air-Retaining Grids Technology" describes a new possibility for the architecture and construction of surfaces which are able to keep a layer of gas stable even under changing pressure conditions when immersed in liquid. Structured, non-wettable surfaces are used for various applications, for example as self-cleaning surfaces.
Enantiomerically pure chiral N-acyl-a-aminonitriles
Enantiomerically pure N-acyl-a-aminonitriles gained these days interest in the pharmaceutical industry since a range of recently developed pharmaceuticals are based on this product class.
P2Y 12-receptor antagonist
Purinergic receptors have been in the focus of drug discovery for many years. Modulation of P2 receptors in platelets is of paramount importance in regulating platelet function, and as a consequence, in controlling thrombotic diseases, which are the most common cause of morbidity and mortality in the Western world.
The present invention relates to polymers from renewable raw materials, as well as monomeric precursors for the production of furan-containing polymers and a production process of both the polymers and the precursors. The 5-HMF derivatives serve as monomers for, among others, biodegradable polyesters, polyamides, polyimines and polyurethanes.
Novel raw material input for the production of green steel. In addition to hydrogen, a carbon-containing aerosol is used to produce green steel.
The new mechanochemical process developed by scientists at Ruhr- Universität Bochum describes the synthesis of hydroxyaryl ketones in which, for the first time, the Fries rearrangement is carried out in the liquid and solid phases in ball mills and extruders. The rearrangement is carried out while avoiding solvents both at room temperature and at elevated temperatures. This can increase safety, while reducing costs.
Mechanochemical synthesis of HAT-CN by condensation of hexaketocyclohexane and diaminomaleonitrile in refluxing acetic acid. The new process, which was developed by scientists at the Ruhr University of Bochum, is the first to synthesize HAT-CN in the solid phase using a ball mill or extruder. A major advantage over conventional synthesis is the complete absence of organic solvents, making production safer and reducing the amount of hazardous substances in circulation.
The present invention is an environmentally friendly process as a substitute for common synthesis routes for sulfuric acid-free phenol and acetone synthesis.
An Invention for prevention of bacterial infection by applying an antimicrobial latex for a surface coating that is mechanically stabilized by chemical or photochemical crosslinking
The present invention allows to print the conduits submerged in non-miscible solvents of high density, such as fluorocarbons (e.g. C12F27N), that support the printed structure while it is being generated resulting in superior performance in relation to other methods. Viable cells 24 h after the printing process, as well as after 21 days in culture.
3D-TAM (Tumour Angiogenesis Model)
This model can be used to analyse tumour groth, tumour angiogenesis and therapeutic effects on the 3D-printed cell model. No animal tissue is needed. Therefore, this 3D-printed Tumour Model represents an ideal in-vitro-prescreening system for testing pharmaceuticals and diagnostics and might be able to circumvent or at least reduce the number of animal tests in drug development.
Hydrophobic Phytic Acid Conversion
The innovation presented here concerns the production and use of hydrophobic phytic acid derivatives as an environmentally friendly alternative to conventional phosphate corrosion protection pre-treatments for steel.
Spray freeze-drying combines the advantageous properties of the well-established techniques spray drying and freeze-drying.
High-Redshift BODIPY Dyes
Fluorescent molecules are widely used in bioimaging and medicinal applications for several decades due to their high sensitivity and easy visibility.
Enzymatic reactions offer the possibility to synthesize new molecules with high selectivity and turnover.
Scientists from Hamm-Lippstadt University of Applied Sciences and the University of Siegen have developed halogen-free polystyrenes that intrinsically contain flame retardant components in the polymer chain.