Innovative high-performance chemicals, analytical methods, innovative materials – PROvendis offers a wide range of chemical technologies for licensing, to purchase or for development cooperation.
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Photocage Cap for mRNAs
Almost all eukaryotic messenger RNAs (mRNAs) are modified at their 5'-ends by a cap that is synthesised by addition of a 7-methylguanosine attached via a 5'-5' triphosphate bridge to the first transcribed nucleotide of the mRNA chain.
Industrial filter bags with catalytic properties are state of the art. They consist of a multi-layer fabric, containing catalytic particle in the intermediate space. Due to this construction, there is a huge pressure lost and cost for an additional fabric layer.
Scientists at the University of Bielefeld developed asymmetric derivates of the so called Finland-Trityls for spectroscopic and analytical use.
The present invention "Air-Retaining Grids Technology" describes a new possibility for the architecture and construction of surfaces which are able to keep a layer of gas stable even under changing pressure conditions when immersed in liquid. Structured, non-wettable surfaces are used for various applications, for example as self-cleaning surfaces.
Enantiomerically pure chiral N-acyl-a-aminonitriles
Enantiomerically pure N-acyl-a-aminonitriles gained these days interest in the pharmaceutical industry since a range of recently developed pharmaceuticals are based on this product class.
P2Y 12-receptor antagonist
Purinergic receptors have been in the focus of drug discovery for many years. Modulation of P2 receptors in platelets is of paramount importance in regulating platelet function, and as a consequence, in controlling thrombotic diseases, which are the most common cause of morbidity and mortality in the Western world.
This invention affects new sensitizers for photo-induced polymerization, their use, and processes for performing photo-induced polymerization with the new sensitizers.
The present invention is an environmentally friendly process as a substitute for common synthesis routes for sulfuric acid-free phenol and acetone synthesis.
An Invention for prevention of bacterial infection by applying an antimicrobial latex for a surface coating that is mechanically stabilized by chemical or photochemical crosslinking
The present invention allows to print the conduits submerged in non-miscible solvents of high density, such as fluorocarbons (e.g. C12F27N), that support the printed structure while it is being generated resulting in superior performance in relation to other methods. Viable cells 24 h after the printing process, as well as after 21 days in culture.
3D-TAM (Tumour Angiogenesis Model)
This model can be used to analyse tumour groth, tumour angiogenesis and therapeutic effects on the 3D-printed cell model. No animal tissue is needed. Therefore, this 3D-printed Tumour Model represents an ideal in-vitro-prescreening system for testing pharmaceuticals and diagnostics and might be able to circumvent or at least reduce the number of animal tests in drug development.
Hydrophobic Phytic Acid Conversion
The innovation presented here concerns the production and use of hydrophobic phytic acid derivatives as an environmentally friendly alternative to conventional phosphate corrosion protection pre-treatments for steel.
Spray freeze-drying combines the advantageous properties of the well-established techniques spray drying and freeze-drying.
High-Redshift BODIPY Dyes
Fluorescent molecules are widely used in bioimaging and medicinal applications for several decades due to their high sensitivity and easy visibility.
Enzymatic reactions offer the possibility to synthesize new molecules with high selectivity and turnover.
Scientists from Hamm-Lippstadt University of Applied Sciences and the University of Siegen have developed halogen-free polystyrenes that intrinsically contain flame retardant components in the polymer chain.
Scientists at the University of Bielefeld successfully synthesized tetrakis(perfluoralkyl)gallate, tetrakis(perfluoralkenyl)gallate, and tetrakis(perfluoralkinyl)gallate