PROvendis offers innovative medical technologies and products for licensing, to purchase or for development cooperation. The portfolio includes medical devices and complex medical equipment, implants, prosthetic devices, stents, and catheters.
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Non-invasive glucose measurement
Regular blood sugar measurement is important for diagnosing and treating diabetes mellitus, a metabolic disorder characterized by high blood sugar. Blood sugar can be measured in a variety of ways, but the current method of choice is invasive: a small blood sample to determine sugar concentration.
Rotary piston pump
So far, the problem of sealing has been a major challenge when using rotary piston pumps.
EasyDMEK Shooter and PrepLoad Tool
The invention comprises a DMEK injection device with a special design, which simplifies the release and unfolding of the membrane into the recipient´s eye during surgery. Therefore, the number of subsequent surgical steps and the likelihood of complications is reduced and consequently the success rate of this surgical method is increased. Corneal transplantation is the most successful organ transplantion in medicine and performed on patients with endothelial dysfunction. In a surgery procedure called DMEK (Descemet Membrane Endothelial Keratoplasty), the inner layer of the cornea, the Descemet's membrane, is replaced with a donor membrane. There is also a device for preparing a Descemet membrane endothelial graft and loading an injection or cultivation cartridge.
Cartilage-specific antimicrobial CLEC3A
Bacterial infection is one of the most frequent complications in joint replacement and dental implant surgery. The incidence of septic arthritis following total joint arthroplasty is approximately 2%, leading to massive health problems and considerable cost to the national economy.
HypoxieFit
Athletes, such as marathon runners and cyclists, often resort to training at higher altitude areas, in order to optimize their endurance. The atmosphere in such locations has lower oxygen content, which forces the human body to compensate for the reduced oxygen uptake by increasing hemoglobin concentration in blood.
Automatically adapting sole
Scientists at Münster University of Applied Sciences have developed a smart insole for diabetic foot syndrome (DFS) that can prevent the majority of foot ulcers. The air cushion insole automatically detects areas under heavy strain by measuring pressure and relieves them by redistributing the air pressure in the individual air cushions.
OCT scanners with better insights
The invention from the University of Bonn is based on a software-based method for determining the autofluorescence of the fundus of the eye using optical coherence tomography. By integrating the software, manufacturers of OCT scanners can both significantly expand the range of functions of their devices and reduce examination times.
Fabric valve leaflet (ribbon valve leaflet)
The University Hospital Aachen has developed a new type of heart valve prosthesis for implantation in the human or animal body. The valve prosthesis consists of a valve stent with a ring-shaped, lower valve base and a valve leaflet consisting of one or more ligament tissues. The tissue made of polymer threads serves as the basic biomechanical structure for the formation of artificial valve leaflets for heart and venous valves.
Test bench for orthoses
Scientists have developed a method and a test stand that can be used to measure the stiffness of orthoses. The test stand makes it easy and convenient to determine and optimize the mechanical properties of ankle orthoses directly in the medical supply store.
Polymer Wound Dressing
The treatment of chronic and infected wounds remains a major challenge in the healthcare sector. A new development by the University of Siegen and the Amsterdam University Medical Center now offers a promising solution: a therapeutic hydrogel with antimicrobial properties that combats infections - including those caused by multi-resistant bacteria - and detects them at an early stage. This safe, effective technology could revolutionize wound care and significantly improve the healing process.
Procedure for orienting X-ray units
A new technology from Heinrich Heine University based on machine learning (MI) allows X-ray equipment to be automatically adjusted to the respective patient, regardless of the patient's position angle.
Ü- Fix
In Germany alone, the annual healthcare expenditure for diabetic foot syndrome (DFS) is around 2.5 billion euros. Thanks to a new invention, it is now possible to replace the commercially available solutions for foot pieces, which are not optimally adapted to the needs and mobility requirements of patients, with a foot piece for the external fixator, which mechanically bridges the damaged area or fracture in such a way that the loads are applied proximally at this point during movement. The patient can now be mobilized directly regardless of the healing status.
Feedback mechanism for powder inhalers
Correct use of capsule-based powder inhalers increases the effectiveness of the active ingredient. Thanks to the new technology for measuring the flow rate and duration of inhalation, the user receives rapid feedback on the quality of inhalation and can adjust their behavior.
Implantable glucose sensor
The innovative glucose sensor makes it easier for patients to measure their blood glucose. It can be implanted and can remain in the body for a longer period of time. The encapsulation of the sensor due to the foreign body reaction does not interfere with the measurement and reliable results are provided at all times.
E-Walker
Walkers are a great help for elderly or temporarily gait-impaired people. However, if the forces are overestimated, the E-Volator from the Ruhr West University of Applied Sciences can lower a stand plate, the person can climb on and then drive electrically and power-saving to their destination.
Total Toe – The foot expander
The "Total Toe", a training device for the toe flexor muscles, can reduce foot amputations for diabetics. Regular training has been shown to counteract muscle regression and reduce peak pressure under the foot - reducing problematic ulcerations and resulting foot amputations.
Movement optimization training tool
In order to optimize movement execution, athletes need feedback on their own movement progress. This technology can increase both effectiveness and efficiency through an extended reality (XR)-based approach using real-time feedback.
SafeGuard-BR system
The lockable intubation adapter system allows hygienic, protected performance of intensive-care examinations without releasing infectious aerosol particles or droplets into the ambient atmosphere.
Neurostimulation with light
The stimulation of nerve cells with electrical or optical impulses is a field of research with a multitude of new applications in medicine. In the future, optogenetics will be used to research the healing possibilities of neurodegenerative diseases or traumatic injuries by stimulating photosensitized nerve cells.
Continuous 3D printing
In order to be able to use 3D printing systems economically and efficiently in series production, the available installation space in the 3D printer must be used optimally for each print or production batch. Thanks to an inclined arrangement of the build platform, the process offers the opportunity to economically mass-produce components despite a high variety of geometries. This is necessary, for example, for medical technology components that have to be adapted to individual structures or body geometry (e.g. dental orthopedics, sports equipment, etc.) and may also have to be fed continuously without batch operation.
Faster MRI examinations
Magnetic resonance imaging (MRI) is an expensive diagnostic imaging examination. A new method developed by the University of Duisburg-Essen significantly shortens MRI examination times by synthetically generating STIR sequences without the otherwise time-consuming STIR scans.
Dummy foot
The invention uses an individualized foot dummy to provide the possibility of examining the lower leg orthosis in order to enable adequate immobilization. To achieve this, the supporting leg is scanned and then additively manufactured in individual parts.
CMOS biosensors
Production process for a highly sensitive biosensor made from a crossed nanowire-structure field-effect transistor. The cost effective CMOS compatible production process allows for e.g. biosignal monitoring of molecules like c-reactive protein (CRP), cardiac troponin (cTnI), electrogenic cells, or peptides such as amyloid-beta.
Lab-on-a-Chip-System
Magnetic particles are often used to transport and/or separate biomolecules such as DNA or proteins. These particles have biochemically functionalized surfaces and are used as markers in analytical biotechnology and medical technology.
FlexOxy
With extracorporeal membrane oxygenation, the physician only has oxygenators in a few different sizes. A suitable volume would be particularly important for infants and small children in order to relieve the blood circulation.
Extracorporeal apheresis to treat preeclampsia
Pre-eclampsia is caused by an imbalance between the pro-angiogenic factors VEGF and PIGF and the anti-angiogenic factor sFlt-1, because sFlt-1 binds both factors. This binding leads to the inactivation of VEGF and PIGF. The present invention relates to a method by which sFlt-1 is eliminated from blood in an apheresis procedure by passing the blood over a column containing immobilised moVEGF165 or scVEGF165. Simultaneously with sFlt-1 binding, sFlt-1-bound VEGF and PIGF are released so that the angiogenic balance, essential for fetal development, is restored after the return of the two pro-angiogenic factors.