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SelectCells
Extremely mild, selective and efficient technique for separating cells based on temperature-sensitive polymer coating, particularly stem and iPS cells.
Photocage Cap for mRNAs
Almost all eukaryotic messenger RNAs (mRNAs) are modified at their 5'-ends by a cap that is synthesised by addition of a 7-methylguanosine attached via a 5'-5' triphosphate bridge to the first transcribed nucleotide of the mRNA chain.
Artificial Interferons
The invention comprises IFNα2 mutants achieved by designing an IFNα2 with amino acids from IFNα14, which significantly improved their antiviral activity against chronic HBV. As IFNα14 is not suitable for use as a drug, unlike IFNα2, and considering that the IFNα2 mutant is almost as effective as IFNα14, it appears the IFNα2 mutant could be a viable option for clinical application.
Cyclic AMP Biosensor
Cyclic AMP is a key molecule in 2nd messenger cell signalling. Great effort has been taken to develop sensors that allow for noninvasive assessment of cAMP concentrations in living cells.
CCL3-EASER Mouse
The CCL3-EASER (ErAse, SEnd, Receive) mouse is a genetically engineered knock-in model designed to provide unprecedented in vivo resolution of CCL3 expression and signaling dynamics.
Circular RNA
Scientists of the University Hospital Bonn and Stanford University have discovered that mammalian IRES-like sequences can overcome the efficiency limitations of eukaryotic translation initiation in circular RNA therapeutics.
Supplements for T Cell-Based Immunotherapy
Optimized conceot for the activation of CAR T cells and prevention of exhaustion in the treatment of cancer.
Synthetic Cytokine Receptors
Synthetic cytokine receptors (SyCyRs) enable defined background-free cellular responses through addition of synthetic ligands. The system allows the engineering of highly specific amplification or eradication switches for recombinant cells.
OVEMO
Das erfindungsgemäße Liquid-Handling-System ermöglicht erstmals mittels Zentrifugation die hochwertige und sterile Kultivierung von adhärenten Zellen in 384-Well-Mikrotiterplatten.
New Cryptophycins for ADC and SMDC
The present invention combines new synthetic ways to new Cryptophycin derivatives with alternative conjugation possibilites and pico-molar cytotoxicies, for ADC and SMDC synthesis.
High-Redshift BODIPY Dyes
Fluorescent molecules are widely used in bioimaging and medicinal applications for several decades due to their high sensitivity and easy visibility.
Plasma Biocatalysis
Enzymatic reactions offer the possibility to synthesize new molecules with high selectivity and turnover.