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Novel therapeutic for MLD
Metachromatic leukodystrophy (MLD) is a genetic lysosomal accumulation disease caused by the deficiency of the enzymatic activity of arylsulfatase A (ASA).
Prostate cancer is the most common cancer among men. In particular, hormone refractory prostate cancer is not curable and targeted therapies are yet not available.
There are currently 200 million people suffering from osteoporosis worldwide. Low bone mass and deteriorating bone quality lead to an increased risk of fractures, high morbidity and increased mortality.
Chitosans are a family of functional biopolymers, typically produced by partial de-N-acetylation of chitin, one of the most abundant biopolymers in the world.
Click-Mass Spectrometry of lipids
Aberrations in fatty acid metabolism are associated with pathological states and have become a focus of current research, particularly due to the interest in metabolic overload diseases.
Protein delivery into cells by HTRA1
Precise and graded manipulation of protein levels in mammalian cells is an essential experimental tool in both basic research and clinical applications.
High Temperature Requirement A (HTRA) proteins are serine proteases of the S1 family (trypsin/chymotrypsin-like). HTRA1 is supposed to play a role in macular degeneration, and HTRA2 has been associated with cell death in reperfusion-ischemia.
Tuberculosis resulting from infection with Mycobacterium tuberculosis (Mtb) is a serious global health problem accounting for 1.7 million deaths in 2016. A major reason for the high morbidity and mortality caused by Mtb is the long duration of therapy and increasing multidrug-resistance of Mtb strains.
EF-Tu-binding Re-complexed antibiotics
A series of novel Re(I)-(CO)3-N-heterocyclic carbene (NHC) complexes bearing unsubstituted benzimidazol-2-ylidene ligands as well as a variety of bisimine ligands has been prepared and comprehensively characterised.
The generation of cardiomyocytes (CMs) from pluripotent stem cells (PSCs) holds great promise for cardiac regenerative medicine.
Small molecule activators of the Bone Morphogenetic Protein (BMP)-signaling pathway hold promise for many applications in stem cell research such as (cost-)efficient and robust mesodermal differentiation from pluripotent stem cells (e.g., ESCs, iPSCs) or as therapeutics for degenerative bone (and cartilage) diseases (please see relevant publications).
Carbon monoxide (CO), which is endogenously produced mainly in the course of heme degradation, was recently recognized as a powerful cytoprotective and homeostatic agent.
Novel Anti-Tuberculosis Compounds
Novel Mycobacterium tuberculosis thioredoxin reductase inhibitors with antimycobacterial activity in infected macrophages.
Inhibition of IKK complex
The NF-κB signaling pathway plays a pivotal role in a broad range of cellular processes including cell proliferation and survival and is tightly linked to diseases such as cancer.
The need of new drugs is high in many medical indications, for instance in oncology, and infectious diseases. However, the success rate of drug research and development has declined to unsustainable levels.
A Multifunctional Linker for CAR T-cells
A human CD34 hinge region allows detection as well as rapid CliniMACS-mediated enrichment of successfully engineered CAR-expressing immune effector cells and reduces adverse side-effects
CEACAM1 antibodies for anti-viral therapy
Cytotoxic CD8-positive T cells constitute the crucial leukocyte subpopulation for a cellular response against viral infection.
Centrosomes are major microtubule organizing centers in mammalian cells, which play a pivotal role in mitosis. Centrosome amplification is a hallmark of human cancers that can trigger cancer cell invasion.
Selective Enhancement of Ligands by Exponential Enrichment (SELEX) has proven to be a powerful tool for idenfying functional oligonucleotides which bind to selected targets.
P2Y 12-receptor antagonist
Purinergic receptors have been in the focus of drug discovery for many years. Modulation of P2 receptors in platelets is of paramount importance in regulating platelet function, and as a consequence, in controlling thrombotic diseases, which are the most common cause of morbidity and mortality in the Western world.
Induced Somatic Stem Cells
Since the pioneer work published by Takahashi & Yamanaka, the technique of reprogramming cells from a differentiated to an embryonic-like status has experienced an exploding development in regard to both techniques and applications.
Parthenolide and its derivatives for use in the treatment of axonal damage
Peripheral nerve damage is a common cause of considerable functional morbidity, and healthcare expenditure.
The formation and onset of the prevalent form of acute myeloid leukemia (AML, FAB subtype M2) requires RUNX1/ETO, the product of the t(8;21) chromosomal translocation.
Cure for CLL
Chronic lymphocytic leukemia (CLL) is the most common adult leukemia in Western countries. The disease is very heterogeneous with some patients showing extremely slow progression while others proceed rapidly into advanced disease stages and require immediate treatment.
Druggable oncogenic fusions
Cancer patients frequently bear therapeutically relevant genome alteration. For instance, lung adenocarcinomas of patients that have never smoked carry genome alterations affecting kinases, such as EGFR mutations and translocations affecting ALK, ROS1 and RET genes.
Targeted therapy has become a promising therapeutic approach within the last decade due to its reduced toxicity.
Adenosine is a modulator of many physiological and pathophysiological processes in the central nervous system (CNS).
There is no satisfactory therapy to prevent the loss of synapses, axons or neurons in neurodegenerative diseases, such as age-related macular degeneration (AMD), multiple sclerosis and Alzheimer’s disease.
Exosomes are nano-sized, secreted cell organelles that are released by a huge variety of different cell species, including mesenchymal stem cells (MSCs). Containing a combination of lipids and proteins as well as RNAs, exosomes participate in intercellular communication processes.
CorA as anthelmintic (Human filariasis)
Human filariasis (elephantiasis and river blindness) is caused by the nematodes W. bancrofti and O. volvulus, transmitted via blood sucking insects.
NMDAR Antagonists as new Antidiabetic Medication
According to the International Diabetes Federation (IDF), diabetes affects close to 400 million people worldwide and caused 500 billion Euros in health expenditure in 2013.