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Cyclic AMP Biosensor
Cyclic AMP is a key molecule in 2nd messenger cell signalling. Great effort has been taken to develop sensors that allow for noninvasive assessment of cAMP concentrations in living cells.
OptoRyR
Light-induced opening of the Ryanodine receptor for use as a scalable system in drug screening.
Anoctamin-6/Tmem16f -deficient mice
During skeletogenesis, Anoctamin6/Tmem16F (Ano6) mRNA is expressed in differentiating and mature osteoblasts. Therefore, Ano6-deficient mice serve as a model for studying osteoporosis.
Arylsulfatase A knock-out mice
These mice can be used as a model to study metachromatic leukodystrophy, which is caused by a loss of arylsulfatase A function and consequently by sulfatide accumulation.
Gfi1(1b/1b) and Gfi1(P2A/P2A) Mice
The Snail/Gfi1 (SNAG) family of zinc finger proteins is a group of transcriptional repressors. Gfi1 is a transcriptional repressor being expressed in the hematopoietic and nervous system. Loss of function leads to severe defects in hematopoiesis and inner ear development.
Uveal Melanoma Cell Line with monosomy 3
Uveal melanoma is the most common intraocular malignancy. Approximately 50% of uveal melanoma patients die of metastases, which mainly arise from primary tumors with loss of an entire chromosome 3.
Induced Pluripotent Stem Cells (iPSC) of Patients with Heart Diseases
The iPSCs were generated from reprogrammed human dermal fibroblasts. The fibroblasts were derived from patients with heart diseases of distinct genetic background. Controls of healthy volunteers are also available.
Antibody against extracellular matrix (ECM)-components
The polyclonal antibodies are directed against the following proteins of the extracellular matrix: laminin 1, laminin 5, nidogen 1, nidogen 2, cartilage oligomeric matrix protein (COMP).
Antibody against Amyloid-beta phosphorylated at Ser 8 and 26
The antibodies are directed against specific phosphorylation sites of Amyloid-beta at serine 8 or at serine 26, respectively. Forms of Amyloid beta phosphorylated at these serine residue have increased propensity to form toxic aggregates as compared to non-phosphorylated species.
Antibody against the ABD domain of Nesprin-2 Giant
The antibody is directed against the aminoterminal actin-binding domain (ABD) of human Nesprin-2 Giant. Nesprin 2 Giant, also referred to as Enaptin and NUANCE, is involved in the maintenance of nuclear organization and structural integrity.
Antibody against CEACAM1
The antibody is directed against the A1/B1-domains of the carcinoembryonic antigen related cell adhesion molecule 1 (CEACAM1). CEACAM1 has been detected at elevated levels in tumors and tumor environment and may thus be a suitable biomarker for the diagnosis and staging of tumors.
Antibody against Amyloid-beta nitrated at Tyr10
The antibody is directed against Amyloid-beta, which is nitrated at the tyrosine on position 10. This nitration of tyrosine enhances Amyloid-beta aggregation and plaque-formation.
High-Redshift BODIPY Dyes
Fluorescent molecules are widely used in bioimaging and medicinal applications for several decades due to their high sensitivity and easy visibility.