Forschungsmaterial

Neue Targets für die Entwicklung von Medikamenten identifizieren und validieren – PROvendis bietet Forschungsmaterialien wie Antikörper, Zelllinien, Mausmodelle und Vektoren zur Lizenzierung, zum Kauf oder für Entwicklungskooperationen an.

Nehmen Sie Kontakt mit uns auf! Weitere Ansprechpartner*innen finden Sie auch in jedem Technologieangebot.

Kontakt:

Prof. Dr. Frank Entschladen

fe@provendis.info
+49 208 9410520

Cyclic AMP Biosensor

Cyclic AMP is a key molecule in 2nd messenger cell signalling. Great effort has been taken to develop sensors that allow for noninvasive assessment of cAMP concentrations in living cells.

OptoRyR

Light-induced opening of the Ryanodine receptor for use as a scalable system in drug screening.

Anoctamin-6/Tmem16f -deficient mice

During skeletogenesis, Anoctamin6/Tmem16F (Ano6) mRNA is expressed in differentiating and mature osteoblasts. Therefore, Ano6-deficient mice serve as a model for studying osteoporosis.

Arylsulfatase A knock-out mice

These mice can be used as a model to study metachromatic leukodystrophy, which is caused by a loss of arylsulfatase A function and consequently by sulfatide accumulation.

Gfi1(1b/1b) and Gfi1(P2A/P2A) Mice

The Snail/Gfi1 (SNAG) family of zinc finger proteins is a group of transcriptional repressors. Gfi1 is a transcriptional repressor being expressed in the hematopoietic and nervous system. Loss of function leads to severe defects in hematopoiesis and inner ear development.

Uveal Melanoma Cell Line with monosomy 3

Uveal melanoma is the most common intraocular malignancy. Approximately 50% of uveal melanoma patients die of metastases, which mainly arise from primary tumors with loss of an entire chromosome 3.

Induced Pluripotent Stem Cells (iPSC) of Patients with Heart Diseases

The iPSCs were generated from reprogrammed human dermal fibroblasts. The fibroblasts were derived from patients with heart diseases of distinct genetic background. Controls of healthy volunteers are also available.

Antibody against extracellular matrix (ECM)-components

The polyclonal antibodies are directed against the following proteins of the extracellular matrix: laminin 1, laminin 5, nidogen 1, nidogen 2, cartilage oligomeric matrix protein (COMP).

Antibody against Amyloid-beta phosphorylated at Ser 8 and 26

The antibodies are directed against specific phosphorylation sites of Amyloid-beta at serine 8 or at serine 26, respectively. Forms of Amyloid beta phosphorylated at these serine residue have increased propensity to form toxic aggregates as compared to non-phosphorylated species.

Antibody against the ABD domain of Nesprin-2 Giant

The antibody is directed against the aminoterminal actin-binding domain (ABD) of human Nesprin-2 Giant. Nesprin 2 Giant, also referred to as Enaptin and NUANCE, is involved in the maintenance of nuclear organization and structural integrity.

Antibody against Amyloid-beta nitrated at Tyr10

The antibody is directed against Amyloid-beta, which is nitrated at the tyrosine on position 10. This nitration of tyrosine enhances Amyloid-beta aggregation and plaque-formation.

High-Redshift BODIPY Dyes

Fluorescent molecules are widely used in bioimaging and medicinal applications for several decades due to their high sensitivity and easy visibility.