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Cyclic AMP Biosensor
Cyclic AMP is a key molecule in 2nd messenger cell signalling. Great effort has been taken to develop sensors that allow for noninvasive assessment of cAMP concentrations in living cells.
CCL3-EASER Mouse
The CCL3-EASER (ErAse, SEnd, Receive) mouse is a genetically engineered knock-in model designed to provide unprecedented in vivo resolution of CCL3 expression and signaling dynamics.
Mouse models for haematopoiesis and deafness
Mouse models for studying hematopoietic differentiation without severe systemic effects. Mouse models suited for research focusing on erythroid and megakaryocytic lineages. Mouse models for studying defects in granulocyte development and inner ear hair cell biology, in particular deafness. Mouse models with GFP reporter gene additionally available.
OptoRyR
Light-induced opening of the Ryanodine receptor for use as a scalable system in drug screening.
Arylsulfatase A knock-out mice
These mice can be used as a model to study metachromatic leukodystrophy, which is caused by a loss of arylsulfatase A function and consequently by sulfatide accumulation.
Uveal Melanoma Cell Line with monosomy 3
Uveal melanoma is the most common intraocular malignancy. Approximately 50% of uveal melanoma patients die of metastases, which mainly arise from primary tumors with loss of an entire chromosome 3.
Induced Pluripotent Stem Cells (iPSC) of Patients with Heart Diseases
The iPSCs were generated from reprogrammed human dermal fibroblasts. The fibroblasts were derived from patients with heart diseases of distinct genetic background. Controls of healthy volunteers are also available.
Antibody against extracellular matrix (ECM)-components
The polyclonal antibodies are directed against the following proteins of the extracellular matrix: laminin 1, laminin 5, nidogen 1, nidogen 2, cartilage oligomeric matrix protein (COMP).
Antibody against Amyloid-beta phosphorylated at Ser 8 and 26
The antibodies are directed against specific phosphorylation sites of Amyloid-beta at serine 8 or at serine 26, respectively. Forms of Amyloid beta phosphorylated at these serine residue have increased propensity to form toxic aggregates as compared to non-phosphorylated species.
Antibody against the ABD domain of Nesprin-2 Giant
The antibody is directed against the aminoterminal actin-binding domain (ABD) of human Nesprin-2 Giant. Nesprin 2 Giant, also referred to as Enaptin and NUANCE, is involved in the maintenance of nuclear organization and structural integrity.
Antibody against Amyloid-beta nitrated at Tyr10
The antibody is directed against Amyloid-beta, which is nitrated at the tyrosine on position 10. This nitration of tyrosine enhances Amyloid-beta aggregation and plaque-formation.
High-Redshift BODIPY Dyes
Fluorescent molecules are widely used in bioimaging and medicinal applications for several decades due to their high sensitivity and easy visibility.