Fortschrittliche Diagnostik ist unabdingbar, um Krankheiten erfolgreich zu erkennen und zu differenzieren. PROvendis bietet vielfältige Biomarker und Testsysteme in unterschiedlichen Indikationen zur Lizenzierung, zum Kauf oder für Entwicklungskooperationen an.

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Dipl.-Biol. Kordula Kruber
+49 208 9410530


3D-Bewegungserfassungssysteme werden häufig mit Inertialsensoren ausgerüstet – beispielsweise mit räumlich zueinander angeordneten Beschleunigungs- und Drehratensensoren.

Aptamer D3P-21

Prostate cancer is the most common cancer among men. In particular, hormone refractory prostate cancer is not curable and targeted therapies are yet not available.

Combinatory Asthma Endoytping Assay

Asthma is a disease of several subtypes characterized by different severity and a distinct immunological background. Most importantly, several subtypes of allergic asthma need to be correctly identified and distinguished from forms of non-allergic asthma.

Click-Mass Spectrometry of lipids

Aberrations in fatty acid metabolism are associated with pathological states and have become a focus of current research, particularly due to the interest in metabolic overload diseases.

Diagnosis of osteoarthritis

Osteoarthritis (OA) is the most common degenerative disease of joints world-wide. About two-third of people over 65 years are affected, whereas the etiology is largely unclear.

Novel Markers for Male Fertility Diagnosis

Infertility affects an estimated 15 percent of couples globally, amounting to 48.5 million couples. Forty percent of cases are linked to men. An important factor of male infertility is an insufficient quality of sperms due to abnormal shape and/or motility.

A Novel Marker for Brown Fat Activity

Brown adipose tissue (BAT) is a special type of fat, which regulates the body temperature by fatty acid oxidation.

Druggable oncogenic fusions

Cancer patients frequently bear therapeutically relevant genome alteration. For instance, lung adenocarcinomas of patients that have never smoked carry genome alterations affecting kinases, such as EGFR mutations and translocations affecting ALK, ROS1 and RET genes.

Epigenetics in AML

DNA-methylation (DNAm) of CpG dinucleotides is a key epigenetic process. Upon cell division, the DNAm pattern is maintained on the newly synthesized DNA strand by DNA methyltransferase 1 (DNMT1), whereas DNAm pattern changes are triggered by DNMT3A and DNMT3B that act as de novo methyltransferases.

Determination of the Biological Age

Biological age is influenced by parameters, such as genetic background, disease and lifestyle. Currently, the biological age can be assessed by measuring telomere length, DNA rearrangements or protein alterations.


Long-term culture associated changes need to be considered for quality control of cell preparations. The invention discloses a simple method to track cellular aging based on continuous DNA-methylation changes at six specific CpG sites.


Diabrux is a user-friendly and the first bite film validated in clinical studies for the standardised, quantitative diagnosis of sleep bruxism. Diabrux is worn by the patient like a night splint. The device is based on a hard plate, which is covered by five specifically linked layers with different colours and defined abrasion properties. A fully automated evaluation software is provided for standardized, objective, quantitative analysis. Diabrux facilitates monitoring of bruxism activity. Thus, personalized therapy planning is possible and cost-intensive treatments can be scheduled more accurately.

Verfahren zur Ausrichtung von Röntgen-Anlagen

Eine neue auf maschinellem Lernen (MI) basierte Technologie der Heinrich-Heine-Universität erlaubt es automatisch, Röntgengeräte auf den jeweiligen Patienten einzustellen, und zwar unabhängig vom Lagerungswinkel des Patienten.

ITIH3 - a biomarker for Myasthenia gravis activity

The invention aims at monitoring inter-alpha-trypsin inhibitor heavy chain H3 (ITIH3) in the serum of Myasthenia gravis patients as the first biomarker for the assessment of MG disease activity in clinical routine, e.g. for therapy adjustments. Monitoring can easily be made by quantitative ELISA in routine blood collection. This approach provides objective results, excluding time-of-day dynamics and subjective symptom burden of patients or examiners.

Monitoring of hemophilia

The invention relates to PD1 as a biomarker for monitoring immune tolerance of coagulation factor VIII treatment of hemophilia A patients.

Chromosomal rearrangements in lung cancer

The invention allows to predict tumor responsiveness to FGFR inhibitor treatment, hence, it can serve as a diagnostic tool to guide personalized precision medicine in cancer treatment.

Schnellere MRT-Untersuchungen

Die Magnetresonanztomographie (MRT) ist eine kostspielige bildgebende Diagnostikuntersuchung. Ein neues Verfahren der Universität Duisburg-Essen verkürzt die Untersuchungsdauer im MRT deutlich indem, synthetisch STIR-Sequenzen generiert werden und ohne die sonst üblichen sehr zeitaufwendigen STIR-Scans.

Vim3 and Mxi-2 antibodies

The invention relates to Vimentin3 and Mxi-2 antibodies found for the non-invasive diagnosis of kidney tumors. These antibodies can make a clear differentiation of oncocytoma and RCC types and allow targeted therapeutic measurements.


Magnetische Partikel werden häufig verwendet, um Biomoleküle wie DNA oder Proteine zu transportieren und/oder zu trennen.


Für die histologische Beurteilung länglicher, kleinlumiger Organe (humane Blutgefäße, Nerven, Harnleiter, muriner Darm, etc.) ist eine systematische, präzise und standardisierte Aufarbeitung des Gewebes in Quer- und teilweise auch Längsschnitten erforderlich.

High-Redshift BODIPY Dyes

Fluorescent molecules are widely used in bioimaging and medicinal applications for several decades due to their high sensitivity and easy visibility.