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Combinatory Asthma Endoytping Assay
Asthma is a disease of several subtypes characterized by different severity and a distinct immunological background. Most importantly, several subtypes of allergic asthma need to be correctly identified and distinguished from forms of non-allergic asthma.
Click-Mass Spectrometry of lipids
Aberrations in fatty acid metabolism are associated with pathological states and have become a focus of current research, particularly due to the interest in metabolic overload diseases.
Diagnosis of osteoarthritis
Osteoarthritis (OA) is the most common degenerative disease of joints world-wide. About two-third of people over 65 years are affected, whereas the etiology is largely unclear.
Novel Markers for Male Fertility Diagnosis
Infertility affects an estimated 15 percent of couples globally, amounting to 48.5 million couples. Forty percent of cases are linked to men. An important factor of male infertility is an insufficient quality of sperms due to abnormal shape and/or motility.
A Novel Marker for Brown Fat Activity
Brown adipose tissue (BAT) is a special type of fat, which regulates the body temperature by fatty acid oxidation.
Druggable oncogenic fusions
Cancer patients frequently bear therapeutically relevant genome alteration. For instance, lung adenocarcinomas of patients that have never smoked carry genome alterations affecting kinases, such as EGFR mutations and translocations affecting ALK, ROS1 and RET genes.
Determination of the Biological Age
Biological age is influenced by parameters, such as genetic background, disease and lifestyle. Currently, the biological age can be assessed by measuring telomere length, DNA rearrangements or protein alterations.
Senescence-Methylation-Signature
Long-term culture associated changes need to be considered for quality control of cell preparations. The invention discloses a simple method to track cellular aging based on continuous DNA-methylation changes at six specific CpG sites.
OCT-Scanner mit mehr Durchblick
Die Erfindung aus der Uni Bonn beruht auf einem Software-basierten Verfahren zum Ermitteln von Autofluoreszenz des Augenhintergrundes mittels optischer Kohärenztomographie. Die Hersteller von OCT-Scannern können durch die Integration der Software sowohl den Funktionsumfang Ihrer Geräte deutlich erweitern als auch die Untersuchungszeiten reduzieren.
Innovative ELISA Assays for Non-Invasive Lupus Nephritis Diagnosis
Currently, Lupus Nephritis diagnosis relies on invasive kidney biopsies, as there is no validated biomarker to detect kidney involvement in Systemic lupus erythematosus. The subject-matter of the invention comprises two ELISA-based tests with antibodies against the guanidylated form of the protein YB-1 (YB-1-2G) in serum levels: one to detect YB-1-2G and another to identify autoantibodies against YB-1-2G. These innovations offer significant value by enabling a reliable, non-invasive and valuable addition to early diagnosis of Lupus Nephritis, thereby improving patient care.
Verfahren zur Ausrichtung von Röntgen-Anlagen
Eine neue auf maschinellem Lernen (MI) basierte Technologie der Heinrich-Heine-Universität erlaubt es automatisch, Röntgengeräte auf den jeweiligen Patienten einzustellen, und zwar unabhängig vom Lagerungswinkel des Patienten.
ITIH3 - a biomarker for Myasthenia gravis activity
The invention aims at monitoring inter-alpha-trypsin inhibitor heavy chain H3 (ITIH3) in the serum of Myasthenia gravis patients as the first biomarker for the assessment of MG disease activity in clinical routine, e.g. for therapy adjustments. Monitoring can easily be made by quantitative ELISA in routine blood collection. This approach provides objective results, excluding time-of-day dynamics and subjective symptom burden of patients or examiners.
Chromosomal rearrangements in lung cancer
The invention allows to predict tumor responsiveness to FGFR inhibitor treatment, hence, it can serve as a diagnostic tool to guide personalized precision medicine in cancer treatment.
Schnellere MRT-Untersuchungen
Die Magnetresonanztomographie (MRT) ist eine kostspielige bildgebende Diagnostikuntersuchung. Ein neues Verfahren der Universität Duisburg-Essen verkürzt die Untersuchungsdauer im MRT deutlich indem, synthetisch STIR-Sequenzen generiert werden und ohne die sonst üblichen sehr zeitaufwendigen STIR-Scans.
Lab-on-a-Chip-System
Magnetische Partikel werden häufig verwendet, um Biomoleküle wie DNA oder Proteine zu transportieren und/oder zu trennen.
High-Redshift BODIPY Dyes
Fluorescent molecules are widely used in bioimaging and medicinal applications for several decades due to their high sensitivity and easy visibility.